| Ischaemic related transitory left ventricular dysfunction in 201Tl gated SPECT. | |
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MedLine Citation:
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PMID: 15942480 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To report our data concerning the changes in post-stress and at-rest left ventricular ejection fraction and ventricular volumes in patients with thallium gated SPECT. METHODS: Post-stress and at-rest thallium gated SPECT was performed in 629 consecutive patients; left ventricular ejection fraction (LVEF), left ventricular volumes and quantitative perfusion data were obtained. Transitory left ventricular dysfunction was diagnosed when post-stress LVEF did not increase at least 5% from LVEF at-rest. RESULTS: In all patients post-stress LVEF was 64%+/-17 while at-rest LVEF was 66%+/-15 (P=0.6). Post-stress end diastolic volume (EDV) was 142 ml+/-7, at-rest EDV was 141 ml+/-92 (P=0.57), post-stress end systolic volume (ESV) was 54 ml+/-51 and at-rest ESV was 56 ml+/-59 (P=0.38). Data from the perfusion study were used to divide patients into three groups: normal patients (group I), patients with total or partially reversible defects (group II) and patients with fixed defects (group III). In group I and group III patients LVEF at-rest was lower than post-exercise (LVEF 75%+/-11 vs 81%+/-10 (P<0.001) and 57%+/-16 vs 60%+/-18 (P=0.025)), respectively. Patients in group II had a higher at-rest LVEF than post-exercise (LVEF 66%+/-14 vs 64%+/-16 (P=0.003)). While the left ventriuclar volumes in group I and III patients decreased with exercise, group II patients had increased post-stress ESV. CONCLUSIONS: Post-stress and at-rest LVEF are similar when all patients are considered but significant differences appear when patients are divided according to the results of the perfusion study. Normal and fixed defect patients have increased post-exercise LVEF. Patients with reversible defects have decreased LVEF, which is largely due to an increased ESV. Transitory left ventricular dysfunction is related to the presence of reversibility and may benefit from revascularization. |
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Authors:
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Maria del Val Gómez; Félix G Gallardo; Miguel A San Martín; Angel Garcia; Ignacio Terol |
Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Nuclear medicine communications Volume: 26 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 2005 Jul |
Date Detail:
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Created Date: 2005-06-08 Completed Date: 2005-11-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: England |
Other Details:
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Languages: eng Pagination: 601-5 Citation Subset: IM |
Affiliation:
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Department of Nuclear Medicine, Hospital Carlos III, Madrid, Spain. mgomez.hciii@salud.madrid.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Exercise Test Female Gated Blood-Pool Imaging / methods* Humans Male Middle Aged Myocardial Ischemia / complications, radionuclide imaging* Prognosis Radiopharmaceuticals / diagnostic use Reproducibility of Results Rest Risk Assessment / methods Risk Factors Sensitivity and Specificity Stroke Volume* Thallium / diagnostic use* Tomography, Emission-Computed, Single-Photon / methods* Ventricular Dysfunction, Left / etiology, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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