Document Detail


Ischaemic postconditioning: from bench to bedside ...
MedLine Citation:
PMID:  19104728     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and low-income countries necessitates the development of myocardial salvaging/protection interventions, to be applied alongside standard reperfusion therapies. Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. The recently described phenomenon of postconditioning (postC), or short cycles of reperfusion/ischaemia applied at the onset of reperfusion, falls within the clinically relevant time period of reperfusion, but can it elicit reliable and potent cardioprotection? The answer to this problem is intimately related to the question whether postC can be translated from a laboratory technique to a clinical therapy. In this brief overview of postconditioning, the experimental set-ups and postC algorithms utilised, and their associated outcomes in all animal models studied (dog, rabbit, mouse, rat and pig) are discussed. The therapeutic potential of postC is also addressed by discussing reported preliminary studies on the efficacy and feasibility of postC (both ischaemic and pharmacological) in humans.
Authors:
Derick van Vuuren; Amanda Lochner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiovascular journal of Africa     Volume:  19     ISSN:  1995-1892     ISO Abbreviation:  -     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-12-23     Completed Date:  2009-03-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101313864     Medline TA:  Cardiovasc J Afr     Country:  South Africa    
Other Details:
Languages:  eng     Pagination:  311-20     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Division of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, South Africa. dvvuuren@sun.ac.za
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Animals
Cardiovascular Agents / therapeutic use*
Cells, Cultured
Disease Models, Animal
Dogs
Humans
Ischemic Preconditioning, Myocardial
Mice
Myocardial Ischemia / pathology,  therapy*
Myocardial Reperfusion*
Myocardial Reperfusion Injury / pathology,  prevention & control*
Myocardium / pathology*
Rabbits
Rats
Swine
Chemical
Reg. No./Substance:
0/Cardiovascular Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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