| Ischaemic postconditioning: from bench to bedside ... | |
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MedLine Citation:
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PMID: 19104728 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The increase in the incidence of ischaemic heart disease and acute myocardial infarction (AMI) in both high- and low-income countries necessitates the development of myocardial salvaging/protection interventions, to be applied alongside standard reperfusion therapies. Although the phenomenon of ischaemic preconditioning (IPC) is associated with the desired protective capacity, the necessity of its application before sustained ischaemia limits its clinical potential. The recently described phenomenon of postconditioning (postC), or short cycles of reperfusion/ischaemia applied at the onset of reperfusion, falls within the clinically relevant time period of reperfusion, but can it elicit reliable and potent cardioprotection? The answer to this problem is intimately related to the question whether postC can be translated from a laboratory technique to a clinical therapy. In this brief overview of postconditioning, the experimental set-ups and postC algorithms utilised, and their associated outcomes in all animal models studied (dog, rabbit, mouse, rat and pig) are discussed. The therapeutic potential of postC is also addressed by discussing reported preliminary studies on the efficacy and feasibility of postC (both ischaemic and pharmacological) in humans. |
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Authors:
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Derick van Vuuren; Amanda Lochner |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cardiovascular journal of Africa Volume: 19 ISSN: 1995-1892 ISO Abbreviation: - Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-12-23 Completed Date: 2009-03-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101313864 Medline TA: Cardiovasc J Afr Country: South Africa |
Other Details:
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Languages: eng Pagination: 311-20 Citation Subset: IM |
Affiliation:
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Department of Biomedical Sciences, Division of Medical Physiology, Faculty of Health Sciences, University of Stellenbosch, South Africa. dvvuuren@sun.ac.za |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Algorithms Animals Cardiovascular Agents / therapeutic use* Cells, Cultured Disease Models, Animal Dogs Humans Ischemic Preconditioning, Myocardial Mice Myocardial Ischemia / pathology, therapy* Myocardial Reperfusion* Myocardial Reperfusion Injury / pathology, prevention & control* Myocardium / pathology* Rabbits Rats Swine |
| Chemical | |
Reg. No./Substance:
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0/Cardiovascular Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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