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Ischaemic colitis during interferon treatment for chronic hepatitis C: report of two cases and literature review.
MedLine Citation:
PMID:  22239522     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Summary.  Ischaemic colitis is known to be a severe emergency complication of interferon (IFN) therapy. However, as ischaemic colitis is an infrequent complication of IFN therapy, limited information is available regarding the safety of resuming IFN therapy after resolution of ischaemic colitis and subsequent recurrence. Here, we report two cases of ischaemic colitis during IFN therapy for chronic hepatitis C. Ischaemic colitis was fully healed within 1 week after its onset and IFN withdrawal, and IFN therapy was resumed following patients' wishes to do so. Ischaemic colitis did not recur after the resumption of IFN therapy, and sustained virological response was achieved in both patients. In this report, we also summarize the findings of 11 cases of IFN-associated ischaemic colitis (nine previously published cases plus our two cases) and review the clinical characteristics of ischaemic colitis during IFN therapy in patients with chronic hepatitis C.
Authors:
T Kawaguchi; T Ide; M Itou; M Suetsugu; S Yoshioka; M Sakata; E Taniguchi; T Oriishi; S Sumie; O Tsuruta; M Sata
Publication Detail:
Type:  Journal Article     Date:  2011-08-04
Journal Detail:
Title:  Journal of viral hepatitis     Volume:  19     ISSN:  1365-2893     ISO Abbreviation:  J. Viral Hepat.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9435672     Medline TA:  J Viral Hepat     Country:  England    
Other Details:
Languages:  eng     Pagination:  e220-4     Citation Subset:  IM    
Copyright Information:
© 2011 Blackwell Publishing Ltd.
Affiliation:
Department of Digestive Disease Information & Research Department of Medicine, Kurume University School of Medicine GI Center, Kurume University Hospital, Kurume, Japan.
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