Document Detail

Ischaemic brain damage induced by rapid lowering of arterial pressure in hypertension.
MedLine Citation:
PMID:  6530542     Owner:  NLM     Status:  MEDLINE    
Mean arterial pressure (MAP) and cerebral blood flow were monitored in six normotensive [MAP = 99 +/- 3 mmHg (s.e.m.)] and seven baboons with renovascular hypertension (MAP = 140 +/- 5 mmHg). Arterial pressure was decreased sufficiently rapidly and for a sufficient time, as determined by the electroencephalogram (EEG), to result in ischaemic brain damage. Using a combination of a bolus injection of trimetaphan, head-up tilt and acute withdrawal of blood, an isoelectric EEG was achieved at a higher MAP in the hypertensive (32 +/- 2 mmHg) than in the normotensive (19 +/- 1 mmHg: P less than 0.001) animals. Cerebral blood flow decreased to an equivalent degree in both groups. Ischaemic brain damage accentuated in the arterial boundary zones was seen in five normotensive and six hypertensive animals. This is further evidence that the resistance vessels in chronic hypertension may limit the degree of hypotension (therapeutic or accidental) that can be tolerated by the hypertensive patient.
D I Graham; A McGeorge; W Fitch; J V Jones; E T MacKenzie
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  2     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1985-04-26     Completed Date:  1985-04-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  297-304     Citation Subset:  IM; S    
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MeSH Terms
Blood Pressure*
Brain / pathology
Brain Ischemia / etiology*,  pathology
Cerebrovascular Circulation
Hypertension, Renovascular / complications*,  physiopathology
Hypotension / complications,  physiopathology

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