| Ischaemia-reperfusion mechanisms in acute pancreatitis. | |
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MedLine Citation:
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PMID: 8865466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of ischaemia in the pathogenesis of acute pancreatitis is unknown. Some experimental studies have shown that ischaemia has little effect on the pancreas, while others have found an association with pancreatic injury. Ischaemia-reperfusion damage has been well documented in other sites such as the intestine, cardiac muscle, and skeletal muscle. However, in the pancreas, injury is usually seen only after complete ischaemia, which is uncommon clinically. Experimental chronic pancreatitis is characterized by low pancreatic blood flow, low interstitial pH, and impaired pancreatic tissue oxygenation, which are all findings consistent with the ischaemia-reperfusion mechanisms. Acute pancreatitis is also associated with a reduction in pancreatic blood flow and evidence of free radical generation, similarly suggesting the possibility of ischaemia-reperfusion injury. Ethanol ingestion, which is commonly associated clinically with both chronic and acute pancreatitis, may itself contribute to an ischaemic-reperfusion injury. We have shown that administration of ethanol to cats decreases pancreatic blood flow and may also directly activate neutrophils. Further investigation is needed to determine whether or not these findings are also associated with an ischaemia-reperfusion injury. |
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Authors:
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M T Toyama; M P Lewis; A M Kusske; P U Reber; S W Ashley; H A Reber |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: Scandinavian journal of gastroenterology. Supplement Volume: 219 ISSN: 0085-5928 ISO Abbreviation: Scand. J. Gastroenterol. Suppl. Publication Date: 1996 |
Date Detail:
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Created Date: 1997-01-29 Completed Date: 1997-01-29 Revised Date: 2008-02-13 |
Medline Journal Info:
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Nlm Unique ID: 0437034 Medline TA: Scand J Gastroenterol Suppl Country: NORWAY |
Other Details:
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Languages: eng Pagination: 20-3 Citation Subset: IM |
Affiliation:
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Dept. of Surgery, Sepulveda VA Medical Center, Los Angeles, California, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Animals Chronic Disease Ethanol / pharmacology Humans Ischemia Microcirculation Neutrophils / physiology Pancreas / blood supply Pancreatitis / physiopathology* Reactive Oxygen Species / physiology Reperfusion Injury / physiopathology* |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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