Document Detail


Irritant cutaneous reactions to N-methyl-2-pyrrolidone (NMP).
MedLine Citation:
PMID:  1451458     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Several workers in a small electrotechnical company in Norway experienced irritant reactions of the skin after a few days of working with the solvent N-methyl-2-pyrrolidone (NMP). Due to concern about the health risk of commonly-used organic solvents, the company had chosen to use NMP when one of its products had to be treated with a solvent. After 2 days of work with NMP, 10 of the 12 involved workers displayed acute irritant contact dermatitis of the hands. According to published reports, NMP is not considered to be particularly irritant to the skin. The Safety Data Sheet of a Norwegian sales firm contained no information on cutaneous hazards, but the Safety Data Sheet of an American producer of NMP stated the risk of severe dermatitis upon prolonged contact. NMP seems to be more irritant to the human skin than reported thus far.
Authors:
H L Leira; A Tiltnes; K Svendsen; L Vetlesen
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  27     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1993-01-07     Completed Date:  1993-01-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  148-50     Citation Subset:  IM    
Affiliation:
Department of Occupational Medicine, University Hospital of Trondheim, Norway.
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MeSH Terms
Descriptor/Qualifier:
Dermatitis, Irritant / etiology*
Dermatitis, Occupational / etiology*
Electronics
Female
Hand Dermatoses / chemically induced*
Humans
Middle Aged
Norway
Pyrrolidinones / adverse effects*
Chemical
Reg. No./Substance:
0/Pyrrolidinones; 26138-58-9/N-methylpyrrolidone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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