Document Detail


Irritable bowel syndrome patients show enhanced modulation of visceral perception by auditory stress.
MedLine Citation:
PMID:  12526949     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Symptoms in irritable bowel syndrome (IBS) patients are sensitive to psychological stressors. These effects may operate through an enhanced responsiveness of the emotional motor system, a network of brain circuits that modulate arousal, viscerosomatic perception, and autonomic responses associated with emotional responses, including anxiety and anger. The aim of this study was to test the primary hypothesis that IBS patients show altered perceptual responses to rectal balloon distention during experimentally induced psychological stress compared with healthy control subjects. METHODS: A total of 15 IBS patients (nine women and six men) and 14 healthy controls (seven women and seven men) were studied during two laboratory sessions: 1) a mild stress condition (dichotomous listening to two conflicting types of music), and 2) a control condition (relaxing nature sounds). The stress and relaxation auditory stimuli were delivered over a 10-min listening period preceding rectal distentions and during the rectal distentions but not during the distention rating process. Ratings of intensity and unpleasantness of the visceral sensations, subjective emotional responses, heart rate, and neuroendocrine measures (norepinephrine, cortisol, adrenocorticotropic hormone [ACTH], and prolactin) were obtained during the study. RESULTS: IBS patients, but not healthy controls, rated the 45-mm Hg visceral stimulus significantly higher in terms of intensity and unpleasantness during the stress condition compared with the relaxation condition. IBS patients also reported higher ratings of stress, anger, and anxiety during the stress compared with the relaxing condition, whereas controls had smaller and nonsignificant subjective responses. Heart rate measurements, but not other neuroendocrine stress measures, were increased under the stress condition in both groups. CONCLUSION: These findings confirm the hypothesis of altered stress-induced modulation of visceral perception in IBS patients.
Authors:
Britta Dickhaus; Emeran A Mayer; Nazanin Firooz; Jean Stains; Francisco Conde; Teresa I Olivas; Ronnie Fass; Lin Chang; Minou Mayer; Bruce D Naliboff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of gastroenterology     Volume:  98     ISSN:  0002-9270     ISO Abbreviation:  Am. J. Gastroenterol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2003-01-15     Completed Date:  2003-03-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0421030     Medline TA:  Am J Gastroenterol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  IM    
Affiliation:
University of California, Department of Medicine, Los Angeles (UCLA)/CNS: Center for Neurovisceral Sciences & Women's Health, VA Greater Los Angeles Healthcare System, Los Angeles, California 90073, USA.
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MeSH Terms
Descriptor/Qualifier:
Acoustic Stimulation*
Adult
Autonomic Nervous System / physiopathology
Colonic Diseases, Functional / physiopathology*
Female
Humans
Male
Middle Aged
Neurosecretory Systems / physiopathology
Perception*
Severity of Illness Index
Viscera / physiopathology*
Grant Support
ID/Acronym/Agency:
AR46122/AR/NIAMS NIH HHS; DK 48351/DK/NIDDK NIH HHS; NR 04881/NR/NINR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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