Document Detail

Irreversible subcortical dementia following high altitude illness.
MedLine Citation:
PMID:  15072719     Owner:  NLM     Status:  MEDLINE    
In this report, we present the cases of two 63-year-old women who developed high altitude cerebral edema complicated by the occurrence of permanent neuropsychiatric sequelae. They shared a similar clinical course, in that both developed disturbance of consciousness shortly after their arrival at Cuzco, Peru (3500 m), and both developed persistent neuropsychiatric symptoms after resolution of the acute illness. Interestingly, in case 2 there was a 1-month lucid interval between remission of high altitude illness and occurrence of the irreversible neuropsychiatric sequelae. Brain computerized tomography in case 1 and brain magnetic resonance imaging in case 2 disclosed lesions in the globus pallidus bilaterally, suggesting that the neuropsychiatric symptoms in these patients were manifestations of subcortical dementia. The development of high altitude illness was considered to be attributable to mild restrictive lung impairment in case 1 and to a deficient ventilatory response to hypoxia in case 2. It must therefore be borne in mind that irreversible subcortical dementia may be associated with high altitude cerebral edema.
Chie Usui; Yuichi Inoue; Michihiro Kimura; Eiji Kirino; Shigeyuki Nagaoka; Michirou Abe; Toshihiko Nagata; Heii Arai
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  High altitude medicine & biology     Volume:  5     ISSN:  1527-0297     ISO Abbreviation:  High Alt. Med. Biol.     Publication Date:  2004  
Date Detail:
Created Date:  2004-04-09     Completed Date:  2004-07-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100901183     Medline TA:  High Alt Med Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM; S    
Department of Psychiatry, Juntendo University School of Medicine, Tokyo, Japan.
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MeSH Terms
Acute Disease
Altitude Sickness / complications*,  physiopathology*
Brain Edema / complications*,  etiology
Dementia, Vascular / etiology*,  pathology
Globus Pallidus / pathology*
Magnetic Resonance Imaging
Memory Disorders / etiology
Middle Aged
Time Factors
Tomography, X-Ray Computed

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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