| Irreversible sensorineural hearing loss: an unusual side effect of non-steroidal anti-inflammatory drugs. | |
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MedLine Citation:
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PMID: 20650042 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Non-steroidal anti-inflammatory drugs are known to have a number of potential side effects. Here we report a case demonstrating an uncommon complication, irreversible sensorineural deafness. CASE HISTORY: A 41-year-old man with pre-existing cardiac and renal dysfunction (for which his regular medications included furosemide) presumed secondary to a viral myocarditis developed acute sensorineural hearing loss 5 days after commencing treatment with indomethacin 25 mg tds for acute gout. His hearing loss was preceded by the development of tinnitus and failed to recover. CONCLUSION: Permanent deafness is a rare but serious side effect of NSAIDs. Tinnitus developing in patients on these agents should be regarded as a potential warning sign of impending irreversible ototoxicity. |
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Authors:
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S Ahmad; A Bhanji; S Pal; M Karim |
Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: International journal of clinical pharmacology and therapeutics Volume: 48 ISSN: 0946-1965 ISO Abbreviation: Int J Clin Pharmacol Ther Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-23 Completed Date: 2010-09-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423309 Medline TA: Int J Clin Pharmacol Ther Country: Germany |
Other Details:
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Languages: eng Pagination: 514-6 Citation Subset: IM |
Affiliation:
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Department of Renal Medicine, Norfolk and Norwich University Hospital, Norwich, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adult Anti-Inflammatory Agents, Non-Steroidal / adverse effects*, therapeutic use Gout / drug therapy Hearing Loss, Sensorineural / chemically induced* Humans Indomethacin / adverse effects*, therapeutic use Male Tinnitus / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 53-86-1/Indomethacin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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