| Irreversible cell-cycle transitions are due to systems-level feedback. | |
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MedLine Citation:
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PMID: 17603504 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The irreversibility of cell-cycle transitions is commonly thought to derive from the irreversible degradation of certain regulatory proteins. We argue that irreversible transitions in the cell cycle (or in any other molecular control system) cannot be attributed to a single molecule or reaction, but that they derive from feedback signals in reaction networks. This systems-level view of irreversibility is supported by many experimental observations. |
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Authors:
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Bela Novak; John J Tyson; Bela Gyorffy; Attila Csikasz-Nagy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nature cell biology Volume: 9 ISSN: 1465-7392 ISO Abbreviation: Nat. Cell Biol. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-07-02 Completed Date: 2007-09-06 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 100890575 Medline TA: Nat Cell Biol Country: England |
Other Details:
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Languages: eng Pagination: 724-8 Citation Subset: IM |
Affiliation:
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Oxford Centre for Integrative Systems Biology, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. bela.novak@bioch.ox.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Cell Cycle Proteins / physiology* Cell Division / physiology DNA Replication Feedback, Physiological Humans Models, Biological* |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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