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Irreversible Kidney Damage due to Multicentric Castleman's Disease.
MedLine Citation:
PMID:  21499466     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Castleman's Disease (CD) is a rare lymphoproliferative disorder accompanied by marked systemic inflammatory response. Morphological diagnosis of CD requires biopsy of the whole of the involved lymph node tissue. Three histologic variants have already been described in CD morphology (hyaline vascular, plasma-cell, and mixed). In this study, we report a case of a multicentric Castleman's disease of the plasma cell variant type with negative Herpes Virus 8. The clinical presentation of this patient was of systemic amyloidosis as a result of both a delayed diagnosis and medical management. Previously described cases of CD with secondary amyloidosis have been of the localized type. Regardless, long-standing clinical remission of CD by cytotoxic drugs and anti-CD20 antibody therapy was achieved, but the nephrotic syndrome remained irreversible.
Authors:
Fredrik Kahn; Anna Fagerström; Mårten Segelmark; Omran Bakoush
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Publication Detail:
Type:  Journal Article     Date:  2008-06-01
Journal Detail:
Title:  The Libyan journal of medicine     Volume:  3     ISSN:  1993-2820     ISO Abbreviation:  Libyan J Med     Publication Date:  2008  
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-07-14     Revised Date:  2011-07-28    
Medline Journal Info:
Nlm Unique ID:  101299403     Medline TA:  Libyan J Med     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  101-3     Citation Subset:  -    
Affiliation:
Department of Infectious Disease.
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