Document Detail


β-Irradiation (166Ho patch)-induced skin injury in the mini pig: effects on NF-κB and COX-2 expression in the skin.
MedLine Citation:
PMID:  24962420     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
This study evaluated the detrimental effect of β-emission on pig skin model. Skin injury was modeled in mini pigs by exposing them to 50 and 100 Gy of β-emission delivered from holmium-166 patches. Clinicopathological and immunohistochemical changes in exposed skin were monitored for 18 weeks after β-irradiation. β-irradiation induced desquamation at 2-4 weeks, although gradual repair of this damage was evident 6 weeks after irradiation. Changes in basal cell density and skin depth corresponded to the clinically relevant changes. Skin thickness began to decrease 1 week after irradiation, and the skin was thinnest 4 weeks after irradiation. Skin thickness increased transiently during the recovery from irradiation-induced skin injury, which was evident 6-8 weeks after irradiation. Epidermal expression of nuclear factor-kappa (NF-κB) differed significantly between untreated and irradiated areas. One week after irradiation, cyclooxygenase-2 (COX-2) expression was mostly limited to the basal cell layer and was scattered across these cells. High COX-2 expression was detected throughout the full depth of the skin 4 weeks after irradiation. These findings suggest that NF- κB and COX-2 play a role in the subsequent regeneration of epidermal cells following β-irradiation on the skin of the mini-pig.
Authors:
Joong Sun Kim; Kyung Jin Rhim; Won Seok Jang; Sun Joo Lee; Yeonghoon Son; Seung Sook Lee; Sunhoo Park; Sang Moo Lim
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-6-20
Journal Detail:
Title:  Journal of veterinary science     Volume:  -     ISSN:  1976-555X     ISO Abbreviation:  J. Vet. Sci.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-6-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100964185     Medline TA:  J Vet Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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