| Iroquois homeodomain transcription factors in heart development and function. | |
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MedLine Citation:
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PMID: 22628575 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Numerous cardiac transcription factors play overlapping roles in both the specification and proliferation of the cardiac tissues and chambers during heart development. It has become increasingly apparent that cardiac transcription factors also play critical roles in the regulation of expression of many functional genes in the prenatal and postnatal hearts. Accordingly, mutations of cardiac transcription factors cannot only result in congenital heart defects but also alter heart function thereby predisposing to heart disease and cardiac arrhythmias. In this review, we summarize the roles of Iroquois homeobox (Irx) family of transcription factors in heart development and function. In all, 6 Irx genes are expressed with distinct and overlapping patterns in the mammalian heart. Studies in several animal models demonstrate that Irx genes are important for the establishment of ventricular chamber properties, the ventricular conduction system, as well as heterogeneity of the ventricular repolarization. The molecular mechanisms by which Irx proteins regulate gene expression and the clinical relevance of Irx functions in the heart are discussed. |
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Authors:
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Kyoung-Han Kim; Anna Rosen; Benoit G Bruneau; Chi-Chung Hui; Peter H Backx |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Circulation research Volume: 110 ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-05-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: United States |
Other Details:
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Languages: eng Pagination: 1513-24 Citation Subset: IM |
Affiliation:
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DVM, Departments of Physiology and Medicine, 150 College St, Toronto, Ontario, M5S 3E2, Canada. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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