Document Detail


Iroquois homeodomain transcription factors in heart development and function.
MedLine Citation:
PMID:  22628575     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Numerous cardiac transcription factors play overlapping roles in both the specification and proliferation of the cardiac tissues and chambers during heart development. It has become increasingly apparent that cardiac transcription factors also play critical roles in the regulation of expression of many functional genes in the prenatal and postnatal hearts. Accordingly, mutations of cardiac transcription factors cannot only result in congenital heart defects but also alter heart function thereby predisposing to heart disease and cardiac arrhythmias. In this review, we summarize the roles of Iroquois homeobox (Irx) family of transcription factors in heart development and function. In all, 6 Irx genes are expressed with distinct and overlapping patterns in the mammalian heart. Studies in several animal models demonstrate that Irx genes are important for the establishment of ventricular chamber properties, the ventricular conduction system, as well as heterogeneity of the ventricular repolarization. The molecular mechanisms by which Irx proteins regulate gene expression and the clinical relevance of Irx functions in the heart are discussed.
Authors:
Kyoung-Han Kim; Anna Rosen; Benoit G Bruneau; Chi-Chung Hui; Peter H Backx
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Circulation research     Volume:  110     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1513-24     Citation Subset:  IM    
Affiliation:
DVM, Departments of Physiology and Medicine, 150 College St, Toronto, Ontario, M5S 3E2, Canada.
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