| The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila. | |
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MedLine Citation:
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PMID: 10398687 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Iroquois complex (Iro-C) homeodomain proteins allow cells at the proximal part of the Drosophila imaginal wing disc to form mesothoracic body wall (notum). Cells lacking these proteins form wing hinge structures instead (tegula and axillary sclerites). Moreover, the mutant cells impose on neighboring wild-type cells more distal developmental fates, like lateral notum or wing hinge. These findings support a tergal phylogenetic origin for the most proximal part of the wing and provide evidence for a novel pattern organizing center at the border between the apposed notum (Iro-C-expressing) and hinge (Iro-C-nonexpressing) cells. This border is not a cell lineage restriction boundary. |
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Authors:
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R Diez del Corral; P Aroca; J L G mez-Skarmeta; F Cavodeassi; J Modolell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Genes & development Volume: 13 ISSN: 0890-9369 ISO Abbreviation: Genes Dev. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-08-05 Completed Date: 1999-08-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 8711660 Medline TA: Genes Dev Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1754-61 Citation Subset: IM |
Affiliation:
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Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Antónoma de Madrid, Cantoblanco, 28049 Madrid, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / genetics Drosophila Proteins* Drosophila melanogaster / embryology*, genetics, ultrastructure Embryo, Nonmammalian / ultrastructure Eye Proteins / genetics, physiology* Gene Expression Regulation, Developmental* Gene Targeting Genes, Homeobox* Homeodomain Proteins / genetics, physiology* Insect Proteins / genetics, physiology* Mechanoreceptors / embryology Morphogenesis / genetics* Mosaicism Multigene Family* Thorax / embryology Transcription Factors* Wing / embryology |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Eye Proteins; 0/Homeodomain Proteins; 0/Insect Proteins; 0/Transcription Factors; 0/araucan protein, Drosophila; 0/caup protein, Drosophila; 0/mirr protein, Drosophila |
| Comments/Corrections | |
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