Document Detail

The Iroquois homeodomain proteins are required to specify body wall identity in Drosophila.
MedLine Citation:
PMID:  10398687     Owner:  NLM     Status:  MEDLINE    
The Iroquois complex (Iro-C) homeodomain proteins allow cells at the proximal part of the Drosophila imaginal wing disc to form mesothoracic body wall (notum). Cells lacking these proteins form wing hinge structures instead (tegula and axillary sclerites). Moreover, the mutant cells impose on neighboring wild-type cells more distal developmental fates, like lateral notum or wing hinge. These findings support a tergal phylogenetic origin for the most proximal part of the wing and provide evidence for a novel pattern organizing center at the border between the apposed notum (Iro-C-expressing) and hinge (Iro-C-nonexpressing) cells. This border is not a cell lineage restriction boundary.
R Diez del Corral; P Aroca; J L G mez-Skarmeta; F Cavodeassi; J Modolell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Genes & development     Volume:  13     ISSN:  0890-9369     ISO Abbreviation:  Genes Dev.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-08-05     Completed Date:  1999-08-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  8711660     Medline TA:  Genes Dev     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1754-61     Citation Subset:  IM    
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Antónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
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MeSH Terms
Cell Differentiation / genetics
Drosophila Proteins*
Drosophila melanogaster / embryology*,  genetics,  ultrastructure
Embryo, Nonmammalian / ultrastructure
Eye Proteins / genetics,  physiology*
Gene Expression Regulation, Developmental*
Gene Targeting
Genes, Homeobox*
Homeodomain Proteins / genetics,  physiology*
Insect Proteins / genetics,  physiology*
Mechanoreceptors / embryology
Morphogenesis / genetics*
Multigene Family*
Thorax / embryology
Transcription Factors*
Wing / embryology
Reg. No./Substance:
0/Drosophila Proteins; 0/Eye Proteins; 0/Homeodomain Proteins; 0/Insect Proteins; 0/Transcription Factors; 0/araucan protein, Drosophila; 0/caup protein, Drosophila; 0/mirr protein, Drosophila

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