| The Iroquois homeobox genes function as dorsal selectors in the Drosophila head. | |
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MedLine Citation:
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PMID: 10751180 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Iroquois complex (Iro-C) genes are expressed in the dorsal compartment of the Drosophila eye/antenna imaginal disc. Previous work has shown that the Iro-C homeoproteins are essential for establishing a dorsoventral pattern organizing center necessary for eye development. Here we show that, in addition, the Iro-C products are required for the specification of dorsal head structures. In mosaic animals, the removal of the Iro-C transforms the dorsal head capsule into ventral structures, namely, ptilinum, prefrons and suborbital bristles. Moreover, the Iro-C(-) cells can give rise to an ectopic antenna and maxillary palpus, the main derivatives of the antenna part of the imaginal disc. These transformations are cell-autonomous, which indicates that the descendants of a dorsal Iro-C(-) cell can give rise to essentially all the ventral derivatives of the eye/antenna disc. These results support a role of the Iro-C as a dorsal selector in the eye and head capsule. Moreover, they reinforce the idea that developmental cues inherited from the distinct embryonic segments from which the eye/antenna disc originates play a minimal role in the patterning of this disc. |
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Authors:
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F Cavodeassi; J Modolell; S Campuzano |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Development (Cambridge, England) Volume: 127 ISSN: 0950-1991 ISO Abbreviation: Development Publication Date: 2000 May |
Date Detail:
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Created Date: 2000-06-15 Completed Date: 2000-06-15 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8701744 Medline TA: Development Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 1921-9 Citation Subset: IM |
Affiliation:
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Centro de Biología Molecular Severo Ochoa, CSIC and UAM Cantoblanco, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Patterning / genetics Clone Cells Drosophila / embryology*, genetics Drosophila Proteins Eye / embryology*, ultrastructure Gene Expression Regulation, Developmental Genes, Homeobox Genes, Insect* Head / embryology* Histocytochemistry Homeodomain Proteins / metabolism Lac Operon Microscopy, Electron, Scanning Transcription Factors* |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Homeodomain Proteins; 0/Transcription Factors; 0/distal-less protein, insect; 0/homothorax protein, Drosophila |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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