Document Detail


Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants.
MedLine Citation:
PMID:  15447897     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Iron and zinc deficiency are prevalent during infancy in low-income countries.
OBJECTIVES: The objectives were to examine whether a weekly supplement of iron, zinc, iron+zinc, or a micronutrient mix (MM) of 16 vitamins and minerals would alter infant development and behavior.
DESIGN: The participants were 221 infants from rural Bangladesh at risk of micronutrient deficiencies. Development and behavior were evaluated at 6 and 12 mo of age by using the Bayley Scales of Infant Development II and the Home Observation Measurement of Environment (HOME) scale. In this double-blind trial, the infants were randomly assigned to 1 of 5 treatment conditions: iron (20 mg), zinc (20 mg), iron+zinc, MM (16 vitamins and minerals, including iron and zinc), or riboflavin weekly from 6 to 12 mo. Multivariate analyses were conducted to examine the change in development and behavior for each supplementation group, with control for maternal education, HOME score, months breastfed, anemia, growth at 6 mo, and change in growth from 6 to 12 mo.
RESULTS: Iron and zinc administered together and with other micronutrients had a beneficial effect on infant motor development. Iron and zinc administered individually and in combination had a beneficial effect on orientation-engagement. Two-thirds of the infants were mildly anemic, no treatment effects on hemoglobin concentration were observed, and hemoglobin was not associated with measures of development or behavior.
CONCLUSION: The beneficial effects of weekly iron and zinc supplementation on motor development and orientation-engagement suggest that infants benefit from these minerals when administered together.
Authors:
Maureen M Black; Abdullah H Baqui; K Zaman; Lars Ake Persson; Shams El Arifeen; Katherine Le; Scot W McNary; Monowara Parveen; Jena D Hamadani; Robert E Black
Related Documents :
6895107 - Pesticide, heavy metal, and other chemical residues in infant and toddler total diet sa...
6881917 - Iron supplements versus placebo during pregnancy: its effects on iron and folate status...
18284027 - Potentiation of arsenic neurotoxicity by folate deprivation: protective role of s-adeno...
3439947 - Hydrops foetalis in sheep.
20494467 - Toxic exposure in america: estimating fetal and infant health outcomes from 14 years of...
23154757 - Noninvasive measurement of intestinal epithelial damage at time of refeeding can predic...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  80     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-09-27     Completed Date:  2004-10-19     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  903-10     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / complications,  drug therapy,  epidemiology
Bangladesh
Child Development / drug effects*,  physiology
Dietary Supplements
Double-Blind Method
Drug Combinations
Drug Synergism
Exploratory Behavior / drug effects
Female
Growth / drug effects
Humans
Infant
Infant Behavior / drug effects*,  physiology
Infant Nutrition Disorders* / complications,  drug therapy,  epidemiology
Iron, Dietary / administration & dosage*,  therapeutic use
Male
Micronutrients / administration & dosage*,  deficiency,  therapeutic use
Psychomotor Performance / drug effects
Riboflavin / administration & dosage,  therapeutic use
Rural Population
Zinc / administration & dosage*,  deficiency,  therapeutic use
Grant Support
ID/Acronym/Agency:
R01 HD037430/HD/NICHD NIH HHS; R01 HD037430-01/HD/NICHD NIH HHS; R01 HD037430-02/HD/NICHD NIH HHS; R01 HD037430-03/HD/NICHD NIH HHS; R01 HD037430-04/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Drug Combinations; 0/Iron, Dietary; 0/Micronutrients; J41CSQ7QDS/Zinc; TLM2976OFR/Riboflavin
Comments/Corrections
Comment In:
Am J Clin Nutr. 2005 Jul;82(1):201; author reply 201-2   [PMID:  16002820 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein acc...
Next Document:  Determining bioavailability of food folates in a controlled intervention study.