| Iron and zinc supplementation promote motor development and exploratory behavior among Bangladeshi infants. | |
| | |
MedLine Citation:
|
PMID: 15447897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Iron and zinc deficiency are prevalent during infancy in low-income countries. OBJECTIVES: The objectives were to examine whether a weekly supplement of iron, zinc, iron+zinc, or a micronutrient mix (MM) of 16 vitamins and minerals would alter infant development and behavior. DESIGN: The participants were 221 infants from rural Bangladesh at risk of micronutrient deficiencies. Development and behavior were evaluated at 6 and 12 mo of age by using the Bayley Scales of Infant Development II and the Home Observation Measurement of Environment (HOME) scale. In this double-blind trial, the infants were randomly assigned to 1 of 5 treatment conditions: iron (20 mg), zinc (20 mg), iron+zinc, MM (16 vitamins and minerals, including iron and zinc), or riboflavin weekly from 6 to 12 mo. Multivariate analyses were conducted to examine the change in development and behavior for each supplementation group, with control for maternal education, HOME score, months breastfed, anemia, growth at 6 mo, and change in growth from 6 to 12 mo. RESULTS: Iron and zinc administered together and with other micronutrients had a beneficial effect on infant motor development. Iron and zinc administered individually and in combination had a beneficial effect on orientation-engagement. Two-thirds of the infants were mildly anemic, no treatment effects on hemoglobin concentration were observed, and hemoglobin was not associated with measures of development or behavior. CONCLUSION: The beneficial effects of weekly iron and zinc supplementation on motor development and orientation-engagement suggest that infants benefit from these minerals when administered together. |
| | |
Authors:
|
Maureen M Black; Abdullah H Baqui; K Zaman; Lars Ake Persson; Shams El Arifeen; Katherine Le; Scot W McNary; Monowara Parveen; Jena D Hamadani; Robert E Black |
Related Documents
:
|
6895107 - Pesticide, heavy metal, and other chemical residues in infant and toddler total diet sa... 6881917 - Iron supplements versus placebo during pregnancy: its effects on iron and folate status... 18284027 - Potentiation of arsenic neurotoxicity by folate deprivation: protective role of s-adeno... 3439947 - Hydrops foetalis in sheep. 20494467 - Toxic exposure in america: estimating fetal and infant health outcomes from 14 years of... 23154757 - Noninvasive measurement of intestinal epithelial damage at time of refeeding can predic... |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
|
Title: The American journal of clinical nutrition Volume: 80 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2004 Oct |
Date Detail:
|
Created Date: 2004-09-27 Completed Date: 2004-10-19 Revised Date: 2011-09-22 |
Medline Journal Info:
|
Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 903-10 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, University of Maryland School of Medicine, Baltimore, USA. black@peds.umaryland.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Anemia, Iron-Deficiency
/
complications,
drug therapy,
epidemiology Bangladesh Child Development / drug effects*, physiology Dietary Supplements Double-Blind Method Drug Combinations Drug Synergism Exploratory Behavior / drug effects Female Growth / drug effects Humans Infant Infant Behavior / drug effects*, physiology Infant Nutrition Disorders* / complications, drug therapy, epidemiology Iron, Dietary / administration & dosage*, therapeutic use Male Micronutrients / administration & dosage*, deficiency, therapeutic use Psychomotor Performance / drug effects Riboflavin / administration & dosage, therapeutic use Rural Population Zinc / administration & dosage*, deficiency, therapeutic use |
| Grant Support | |
ID/Acronym/Agency:
|
R01 HD037430-01/HD/NICHD NIH HHS; R01 HD037430-02/HD/NICHD NIH HHS; R01 HD037430-03/HD/NICHD NIH HHS; R01 HD037430-04/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Drug Combinations; 0/Iron, Dietary; 0/Micronutrients; 7440-66-6/Zinc; 83-88-5/Riboflavin |
| Comments/Corrections | |
Comment In:
|
Am J Clin Nutr. 2005 Jul;82(1):201; author reply 201-2
[PMID:
16002820
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Glycemic and insulinemic meal responses modulate postprandial hepatic and intestinal lipoprotein acc...
Next Document: Determining bioavailability of food folates in a controlled intervention study.