Document Detail


Iron therapy for improving psychomotor development and cognitive function in children under the age of three with iron deficiency anaemia.
MedLine Citation:
PMID:  23744449     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Iron deficiency and iron deficiency anaemia (IDA) are common in young children. It has been suggested that the lack of iron may have deleterious effects on children's psychomotor development and cognitive function. To evaluate the benefits of iron therapy on psychomotor development and cognitive function in children with IDA, a Cochrane review was carried out in 2001. This is an update of that review. OBJECTIVES: To determine the effects of iron therapy on psychomotor development and cognitive function in iron deficient anaemic children less than three years of age. SEARCH METHODS: We searched the following databases in April 2013: Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, EMBASE, CINAHL, PsycINFO, LILACS, ClinicalTrials.gov and World Health Organization International Clinical Trials Registry Platform (ICTRP). We also searched the reference lists of review articles and reports, and ran citation searches in the Science Citation Index for relevant studies identified by the primary search. We also contacted key authors. SELECTION CRITERIA: Studies were included if children less than three years of age with evidence of IDA were randomly allocated to iron or iron plus vitamin C versus a placebo or vitamin C alone, and assessment of developmental status or cognitive function was carried out using standardised tests by observers blind to treatment allocation. DATA COLLECTION AND ANALYSIS: Two review authors independently screened titles and abstracts retrieved from the searches and assessed full-text copies of all potentially relevant studies against the inclusion criteria. The same review authors independently extracted data and assessed the risk of bias of the eligible studies. Data were analysed separately depending on whether assessments were performed within one month of beginning iron therapy or after one month. MAIN RESULTS: We identified one eligible study in the update search that had not been included in the original review. In total, we included eight trials.Six trials, including 225 children with IDA, examined the effects of iron therapy on measures of psychomotor development and cognitive function within 30 days of commencement of therapy. We could pool data from five trials. The pooled difference in pre- to post-treatment change in Bayley Scale Psychomotor Development Index (PDI) between iron and placebo groups was -1.25 (95% confidence interval (CI) -4.56 to 2.06, P value = 0.65; I(2) = 33% for heterogeneity, random-effects meta-analysis; low quality evidence) and in Bayley Scale Mental Development Index (MDI) was 1.04 (95% CI -1.30 to 3.39, P value = 0.79; I(2) = 31% for heterogeneity, random-effects meta-analysis; low quality evidence).Two studies, including 160 randomised children with IDA, examined the effects of iron therapy on measures of psychomotor development and cognitive function more than 30 days after commencement of therapy. One of the studies reported the mean number of skills gained after two months of iron therapy using the Denver Developmental Screening Test. The intervention group gained 0.8 (95% CI -0.18 to 1.78, P value = 0.11, moderate quality of evidence) more skills on average than the control group. The other study reported that the difference in pre- to post-treatment change in Bayley Scale PDI between iron-treated and placebo groups after four months was 18.40 (95% CI 10.16 to 26.64, P value < 0.0001; moderate quality evidence) and in Bayley Scale MDI was 18.80 (95% CI 10.17 to 27.43, P value < 0.0001; moderate quality evidence). AUTHORS' CONCLUSIONS: There is no convincing evidence that iron treatment of young children with IDA has an effect on psychomotor development or cognitive function within 30 days after commencement of therapy. The effect of longer-term treatment remains unclear. There is an urgent need for further large randomised controlled trials with long-term follow-up.
Authors:
Bo Wang; Siyan Zhan; Ting Gong; Liming Lee
Related Documents :
22200399 - Association of functional status with changes in physical activity: insights from a beh...
24175899 - Moderators of psycho-oncology therapy effectiveness: meta-analysis of therapy character...
23237079 - Autonomic nervous system arousal and cognitive functioning in bipolar disorder.
24360139 - The combined association of depression and socioeconomic status with length of post-ope...
24575529 - Relationship between chewing ability and depressive symptoms.
24885779 - Internet-based cognitive bias modification for obsessive compulsive disorder: study pro...
21546409 - Efficacy of halofuginone lactate in the prevention of cryptosporidiosis in dairy calves.
17075389 - Beyond the checklist: assessing understanding for hiv vaccine trial participation in so...
22451329 - A longitudinal study of postpartum depressive symptoms: multilevel growth curve analyse...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-06
Journal Detail:
Title:  Cochrane database of systematic reviews (Online)     Volume:  6     ISSN:  1469-493X     ISO Abbreviation:  Cochrane Database Syst Rev     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100909747     Medline TA:  Cochrane Database Syst Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  CD001444     Citation Subset:  -    
Affiliation:
Health Science Popularization Research Center, Chinese Academy of Medical Sciences, 9 Dongdan Santiao, Beijing, Beijing, China, 100730.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Delayed luminance and chromatic contrast sensitivity in infants with spontaneously regressed retinop...
Next Document:  Ready-to-use therapeutic food for home-based treatment of severe acute malnutrition in children from...