Document Detail


Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age.
MedLine Citation:
PMID:  18422809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: General iron supplementation to prevent iron deficiency in infants who are iron sufficient when starting supplementation may adversely affect their health. OBJECTIVE: A secondary analysis to explore the effect of iron supplementation on iron-replete (IR; Hb > or =113 g/L and S-ferritin > or =33 microg/L) or non-iron-replete 6-month-old Indonesian infants participating in a large, randomized trial on iron and zinc supplementation. RESULTS: Among the iron-supplemented IR (Fe-IR, n = 80) infants S-ferritin was, compared to non-iron-supplemented (NS) IR infants (NS-IR, n = 74), significantly higher (47.5 vs. 20.7 microg/L, p = 0.04), and S-zinc significantly lower (9.7 vs. 10.5 micromol/L, p = 0.04). Haemoglobin concentration (Hb) did not differ between the Fe-IR and NS-IR groups. Change in weight-for-age z-score (WAZ) from 6 to 12 months and mean WAZ at 12 months was lower in the Fe-IR group compared to the NS-IR group (-1.45 vs. -1.03, p < 0.001 and -1.97 vs. -1.60, p < 0.001, respectively). There was no difference in morbidity between groups. Iron supplementation of non-iron-replete infants increased Hb and S-ferritin, but did not affect S-zinc or anthropometrical indices. CONCLUSION: In our study, iron supplementation of IR infants affected WAZ adversely, whereas iron supplementation to non-iron-replete infants did not affect growth. These results support a cautious approach to iron supplementation of IR infants.
Authors:
Torbjörn Lind; Rosadi Seswandhana; Lars-Ake Persson; Bo Lönnerdal
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2008-04-14
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  97     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-05-07     Completed Date:  2008-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  770-5     Citation Subset:  IM    
Affiliation:
Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. Torbjorn.Lind@epiph.umu.se
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Anemia, Iron-Deficiency / drug therapy*
Body Mass Index
Body Weight*
Child, Preschool
Dietary Supplements*
Female
Growth Disorders / drug therapy*
Humans
India
Infant
Infant, Newborn
Iron Compounds / therapeutic use*
Male
Nutritional Status*
Pilot Projects
Zinc Compounds / therapeutic use
Chemical
Reg. No./Substance:
0/Iron Compounds; 0/Zinc Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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