| Iron supplementation of iron-replete Indonesian infants is associated with reduced weight-for-age. | |
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MedLine Citation:
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PMID: 18422809 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: General iron supplementation to prevent iron deficiency in infants who are iron sufficient when starting supplementation may adversely affect their health. OBJECTIVE: A secondary analysis to explore the effect of iron supplementation on iron-replete (IR; Hb > or =113 g/L and S-ferritin > or =33 microg/L) or non-iron-replete 6-month-old Indonesian infants participating in a large, randomized trial on iron and zinc supplementation. RESULTS: Among the iron-supplemented IR (Fe-IR, n = 80) infants S-ferritin was, compared to non-iron-supplemented (NS) IR infants (NS-IR, n = 74), significantly higher (47.5 vs. 20.7 microg/L, p = 0.04), and S-zinc significantly lower (9.7 vs. 10.5 micromol/L, p = 0.04). Haemoglobin concentration (Hb) did not differ between the Fe-IR and NS-IR groups. Change in weight-for-age z-score (WAZ) from 6 to 12 months and mean WAZ at 12 months was lower in the Fe-IR group compared to the NS-IR group (-1.45 vs. -1.03, p < 0.001 and -1.97 vs. -1.60, p < 0.001, respectively). There was no difference in morbidity between groups. Iron supplementation of non-iron-replete infants increased Hb and S-ferritin, but did not affect S-zinc or anthropometrical indices. CONCLUSION: In our study, iron supplementation of IR infants affected WAZ adversely, whereas iron supplementation to non-iron-replete infants did not affect growth. These results support a cautious approach to iron supplementation of IR infants. |
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Authors:
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Torbjörn Lind; Rosadi Seswandhana; Lars-Ake Persson; Bo Lönnerdal |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2008-04-14 |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 97 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2008 Jun |
Date Detail:
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Created Date: 2008-05-07 Completed Date: 2008-10-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 770-5 Citation Subset: IM |
Affiliation:
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Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden. Torbjorn.Lind@epiph.umu.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Anemia, Iron-Deficiency / drug therapy* Body Mass Index Body Weight* Child, Preschool Dietary Supplements* Female Growth Disorders / drug therapy* Humans India Infant Infant, Newborn Iron Compounds / therapeutic use* Male Nutritional Status* Pilot Projects Zinc Compounds / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Iron Compounds; 0/Zinc Compounds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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