Document Detail

Iron supplementation in preterm infants: a study comparing the effect and tolerance of a Fe2+ and a nonionic FeIII compound.
MedLine Citation:
PMID:  11185665     Owner:  NLM     Status:  MEDLINE    
The more widely used divalent forms of iron (Fe2+) supplementation often lead to gastrointestinal symptoms in preterm infants although little is known about the use of nonionic trivalent iron preparations (FeIII) in these patients. It is especially under this nonionic form that dietary iron is available. For this reason, a randomized controlled study was undertaken to compare the efficacy and the extent of possible side effects in two groups of preterm infants. In one group, the elemental iron was given in the Fe2+ form, while the other group received a nonionic trivalent iron (FeIII) complexed with polysaccharides of low molecular weight. Both groups received 7.5 mg elemental iron daily. Measured parameters in the two study groups did not differ significantly throughout the study period of 14 weeks. Both forms of iron supplementation were well tolerated. However, vomiting, diarrhea, or constipation occurred slightly more often in the group receiving iron supplementation in the Fe2+ form without reaching statistical difference. The authors found a nonionic trivalent polysaccharide-iron complex given as iron supplementation as effective as the generally more favored ferrous sulphate. Since iron therapy is mandatory in the preterm infant, the use of trivalent iron complexes can be considered as a good alternative.
S Naude; S Clijsen; G Naulaers; H Daniels; C Vanhole; H Devlieger
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  40     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-11     Completed Date:  2000-12-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1447-51     Citation Subset:  IM    
Department of Pediatrics, UZ Gasthuisberg Leuven, Belgium.
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MeSH Terms
Dietary Supplements*
Ferric Compounds / adverse effects,  pharmacology*
Ferrous Compounds / adverse effects,  pharmacology*
Infant, Newborn
Obstetric Labor, Premature
Prospective Studies
Reg. No./Substance:
0/Ferric Compounds; 0/Ferrous Compounds

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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