| Iron-sulfur proteins in health and disease. | |
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MedLine Citation:
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PMID: 20060739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron-sulfur (Fe/S) proteins are a class of ubiquitous components that assist in vital and diverse biochemical tasks in virtually every living cell. These tasks include respiration, iron homeostasis and gene expression. The past decade has led to the discovery of novel Fe/S proteins and insights into how their Fe/S cofactors are formed and incorporated into apoproteins. This review summarizes our current knowledge of mammalian Fe/S proteins, diseases related to deficiencies in these proteins and on disorders stemming from their defective biogenesis. Understanding both the physiological functions of Fe/S proteins and how Fe/S clusters are formed will undoubtedly enhance our ability to identify and treat known disorders of Fe/S cluster biogenesis and to recognize hitherto undescribed Fe/S cluster-related diseases. |
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Authors:
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Alex Sheftel; Oliver Stehling; Roland Lill |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-08 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 21 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-05-03 Completed Date: 2010-07-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 302-14 Citation Subset: IM |
Copyright Information:
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2009 Elsevier Ltd. All rights reserved. |
Affiliation:
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Institut für Zytobiologie, Philipps-Universität Marburg, Robert-Koch-Strasse 6, D-35033 Marburg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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ATP-Binding Cassette Transporters
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physiology Anemia, Sideroblastic / physiopathology Animals Cell Nucleus / metabolism Cytosol / metabolism DNA Repair / physiology Electron Transport / physiology Endoplasmic Reticulum / metabolism Gene Expression Regulation / physiology Humans Iron / metabolism Iron-Sulfur Proteins / metabolism, physiology* Mitochondria / metabolism Mitochondrial Diseases / physiopathology |
| Grant Support | |
ID/Acronym/Agency:
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//Canadian Institutes of Health Research |
| Chemical | |
Reg. No./Substance:
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0/ATP-Binding Cassette Transporters; 0/Iron-Sulfur Proteins; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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