| Iron stores and the international variation in mortality from coronary artery disease. | |
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MedLine Citation:
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PMID: 1890983 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Possible roles for iron in coronary artery disease (CAD) have emerged, including contributions to atherogenesis and/or the vulnerability of the myocardium to ischemia/reperfusion events. The value of hepatic storage iron as a potential risk factor for CAD was evaluated independently and in combination with various lipoprotein indices using CAD mortality data from 11 countries along with available data on liver iron stores. CAD mortality rates were found to be best correlated with the liver iron-serum cholesterol product in both men (r = 0.72) and, more importantly, in both genders combined (r = 0.74). It was also found that estimated CAD incidence could be related in a non-linear fashion to iron-cholesterol values in a simple normal distribution model where all subjects above a threshold value of iron-cholesterol were assumed to have CAD. Hepatic iron values thus appear to be useful in describing the differences in CAD due to both diet (and/or culture) and sex. |
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Authors:
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R B Lauffer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 35 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1991 Jun |
Date Detail:
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Created Date: 1991-10-11 Completed Date: 1991-10-11 Revised Date: 2008-08-15 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 96-102 Citation Subset: IM |
Affiliation:
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Department of Radiology, Massachusetts General Hospital, Boston. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cholesterol / blood Coronary Disease / etiology, metabolism, mortality* Female Humans Iron / metabolism* Lipoproteins, HDL / blood Liver / metabolism Male Middle Aged Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Lipoproteins, HDL; 57-88-5/Cholesterol; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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