Document Detail


Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid.
MedLine Citation:
PMID:  18396284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To further investigate peritoneal iron disruption in endometriosis by studying iron storage in peritoneal macrophages of patients with endometriosis compared with controls. DESIGN: Cross-sectional study. SETTING: Academic gynecology research unit in a university hospital. PATIENT(S): Fifty patients undergoing laparoscopy. INTERVENTION(S): Collection of peritoneal fluid samples (N = 50) from patients with (n = 27) and without (n = 23) endometriosis undergoing laparoscopy. MAIN OUTCOME MEASURE(S): Quantification of peritoneal macrophage ferritin by immunocytochemical staining and immunodensitometry and measurement of peritoneal iron, transferrin, ferritin, and prohepcidin concentrations. RESULT(S): The optical density of peritoneal macrophage ferritin staining was statistically significantly higher in endometriosis patients than in controls. Higher iron concentrations, transferrin saturations, and ferritin concentrations were also detected in case of endometriosis. A statistically significant positive correlation was found between the optical density of macrophage ferritin staining and peritoneal iron concentrations in endometriosis and control patients. CONCLUSION(S): Iron storage is statistically significantly increased in peritoneal macrophages of patients with endometriosis and correlates with iron overload in peritoneal fluid. The potential implications of iron accumulation in peritoneal macrophages in case of endometriosis are discussed.
Authors:
Jean-Christophe Lousse; Sylvie Defrère; Anne Van Langendonckt; Jérémie Gras; Reinaldo González-Ramos; Sébastien Colette; Jacques Donnez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-08
Journal Detail:
Title:  Fertility and sterility     Volume:  91     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-05-07     Completed Date:  2009-05-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1668-75     Citation Subset:  IM    
Affiliation:
Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antimicrobial Cationic Peptides / analysis
Ascitic Fluid / metabolism*
Cross-Sectional Studies
Endometriosis / metabolism*
Female
Ferritins / analysis
Humans
Iron / metabolism*
Iron Overload / metabolism*
Macrophages, Peritoneal / metabolism*
Middle Aged
Protein Precursors / analysis
Transferrin / analysis
Chemical
Reg. No./Substance:
0/Antimicrobial Cationic Peptides; 0/Protein Precursors; 0/prohepcidin; 11096-37-0/Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins

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