| Iron storage is significantly increased in peritoneal macrophages of endometriosis patients and correlates with iron overload in peritoneal fluid. | |
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MedLine Citation:
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PMID: 18396284 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To further investigate peritoneal iron disruption in endometriosis by studying iron storage in peritoneal macrophages of patients with endometriosis compared with controls. DESIGN: Cross-sectional study. SETTING: Academic gynecology research unit in a university hospital. PATIENT(S): Fifty patients undergoing laparoscopy. INTERVENTION(S): Collection of peritoneal fluid samples (N = 50) from patients with (n = 27) and without (n = 23) endometriosis undergoing laparoscopy. MAIN OUTCOME MEASURE(S): Quantification of peritoneal macrophage ferritin by immunocytochemical staining and immunodensitometry and measurement of peritoneal iron, transferrin, ferritin, and prohepcidin concentrations. RESULT(S): The optical density of peritoneal macrophage ferritin staining was statistically significantly higher in endometriosis patients than in controls. Higher iron concentrations, transferrin saturations, and ferritin concentrations were also detected in case of endometriosis. A statistically significant positive correlation was found between the optical density of macrophage ferritin staining and peritoneal iron concentrations in endometriosis and control patients. CONCLUSION(S): Iron storage is statistically significantly increased in peritoneal macrophages of patients with endometriosis and correlates with iron overload in peritoneal fluid. The potential implications of iron accumulation in peritoneal macrophages in case of endometriosis are discussed. |
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Authors:
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Jean-Christophe Lousse; Sylvie Defrère; Anne Van Langendonckt; Jérémie Gras; Reinaldo González-Ramos; Sébastien Colette; Jacques Donnez |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-04-08 |
Journal Detail:
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Title: Fertility and sterility Volume: 91 ISSN: 1556-5653 ISO Abbreviation: Fertil. Steril. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-07 Completed Date: 2009-05-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372772 Medline TA: Fertil Steril Country: United States |
Other Details:
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Languages: eng Pagination: 1668-75 Citation Subset: IM |
Affiliation:
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Department of Gynecology, Université Catholique de Louvain, Brussels, Belgium. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antimicrobial Cationic Peptides / analysis Ascitic Fluid / metabolism* Cross-Sectional Studies Endometriosis / metabolism* Female Ferritins / analysis Humans Iron / metabolism* Iron Overload / metabolism* Macrophages, Peritoneal / metabolism* Middle Aged Protein Precursors / analysis Transferrin / analysis |
| Chemical | |
Reg. No./Substance:
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0/Antimicrobial Cationic Peptides; 0/Protein Precursors; 0/prohepcidin; 11096-37-0/Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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