Document Detail

Iron status and risk of cardiovascular disease.
MedLine Citation:
PMID:  9034408     Owner:  NLM     Status:  MEDLINE    
Free Iron, as well as other transition metals, can catalyze free radical formation. For this reason iron is tightly bound to transport and storage proteins to prevent their involvement in free radical formation. It has been hypothesized that increased iron intake or iron stores may promote atherogenesis by increasing free radical formation and oxidative stress. While a coherent, plausible hypothesis as to how transition metals, such as iron, might accelerate the progression of atherosclerosis has been generated from basic research, iron status, measured as dietary iron intake, serum iron, serum ferritin, and transferrin saturation, has been inconsistently associated with cardiovascular disease in human epidemiologic research. In addition, limited data suggest that iron overload states do not appear to be strongly associated with increased risk of atherosclerotic disease. One real limitation of the existing data is the lack of a generally agreed upon and logistically feasible means of assessing iron status in free living humans. Further research, including basic research and large-scale epidemiologic studies, is needed to fully assess the association between iron status and the risk of CVD and other adverse outcomes. At present the currently available data do not support radical changes in dietary recommendations or screening to detect high normal levels nor do they support the need for large-scale randomized trials of dietary restriction or phlebotomy as a means of lowering iron stores.
M C Corti; M Gaziano; C H Hennekens
Related Documents :
22210788 - Multisociety task force for critical care research: key issues and recommendations.
24104788 - A suggested approach for implementing consort guidelines specific to obstetric research.
16980188 - 'your true and proper gender': the barr body as a good enough science of sex.
21591148 - Bridging the educational research-teaching practice gap: the importance of bridging the...
9358348 - May we practise endotracheal intubation on the newly dead?
19851698 - Is animal experimentation fundamental?
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of epidemiology     Volume:  7     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-25     Completed Date:  1997-04-25     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Epidemiology, Demography and Biometry Program, National Institute on Aging, Boston, MA, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arteriosclerosis / epidemiology*,  metabolism
Cardiovascular Diseases / epidemiology*,  metabolism
Case-Control Studies
Cohort Studies
Coronary Disease / epidemiology,  metabolism
Free Radicals
Iron / metabolism*,  physiology
Oxidative Stress
Risk Factors
Reg. No./Substance:
0/Free Radicals; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Physical activity, functional limitations, and the risk of fall-related fractures in community-dwell...
Next Document:  Physical activity protects against coronary death and deaths from all causes in middle-aged men. Evi...