Document Detail


Iron status and risk of cardiovascular disease.
MedLine Citation:
PMID:  9034408     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Free Iron, as well as other transition metals, can catalyze free radical formation. For this reason iron is tightly bound to transport and storage proteins to prevent their involvement in free radical formation. It has been hypothesized that increased iron intake or iron stores may promote atherogenesis by increasing free radical formation and oxidative stress. While a coherent, plausible hypothesis as to how transition metals, such as iron, might accelerate the progression of atherosclerosis has been generated from basic research, iron status, measured as dietary iron intake, serum iron, serum ferritin, and transferrin saturation, has been inconsistently associated with cardiovascular disease in human epidemiologic research. In addition, limited data suggest that iron overload states do not appear to be strongly associated with increased risk of atherosclerotic disease. One real limitation of the existing data is the lack of a generally agreed upon and logistically feasible means of assessing iron status in free living humans. Further research, including basic research and large-scale epidemiologic studies, is needed to fully assess the association between iron status and the risk of CVD and other adverse outcomes. At present the currently available data do not support radical changes in dietary recommendations or screening to detect high normal levels nor do they support the need for large-scale randomized trials of dietary restriction or phlebotomy as a means of lowering iron stores.
Authors:
M C Corti; M Gaziano; C H Hennekens
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of epidemiology     Volume:  7     ISSN:  1047-2797     ISO Abbreviation:  Ann Epidemiol     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-04-25     Completed Date:  1997-04-25     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  9100013     Medline TA:  Ann Epidemiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  62-8     Citation Subset:  IM    
Affiliation:
Epidemiology, Demography and Biometry Program, National Institute on Aging, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Arteriosclerosis / epidemiology*,  metabolism
Cardiovascular Diseases / epidemiology*,  metabolism
Case-Control Studies
Cohort Studies
Coronary Disease / epidemiology,  metabolism
Female
Free Radicals
Humans
Iron / metabolism*,  physiology
Male
Oxidative Stress
Risk Factors
Chemical
Reg. No./Substance:
0/Free Radicals; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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