Document Detail

Iron status and neurobehavioral development of premature infants.
MedLine Citation:
PMID:  15318248     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was conducted to examine the relation between iron status and neurobehavioral development in premature infants. STUDY DESIGN: Infants born before 34 weeks postmenstrual age and who were medically stable were studied. Anemia was defined as hemoglobin < or =10 g/Dl and low iron stores as a serum ferritin concentration < or =75 microg/l. The infants were classified as anemic with low ferritin (Group 1; n=18), anemic with normal ferritin (Group 2; n=14), and nonanemic with normal ferritin (Group 3; n=21). A total of 18 reflexes were behaviorally evaluated at 37 weeks postmenstrual age and "reflex scores" were compared between the groups. Higher scores reflect a greater percentage of abnormal reflexes. RESULTS: Infants in group 1 (anemia/low ferritin) had a significantly higher reflex score (51.45+/-18.32%) than infants in Group 3 (38.32+/-17.75%). Group 2 had an intermediate score (45.40+/-21.70%), but not different from the other two groups. CONCLUSION: These data indicate that low iron status, both measured by anemia and ferritin levels, is related to poorer neurobehavioral status in premature infants.
Rinat Armony-Sivan; Arthur I Eidelman; Amos Lanir; Devora Sredni; Shlomo Yehuda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  24     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-11-23     Completed Date:  2005-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  757-62     Citation Subset:  IM    
Department of Pediatrics, Shaare-Zedek Medical Center, Jerusalem, Israel.
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MeSH Terms
Birth Weight
Child Development / physiology*
Ferritins / blood
Gestational Age
Hemoglobins / metabolism*
Infant Behavior / physiology*
Infant, Newborn
Infant, Premature / physiology*,  psychology*
Reflex / physiology*
Reg. No./Substance:
0/Hemoglobins; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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