Document Detail

Iron status and iron balance during pregnancy. A critical reappraisal of iron supplementation.
MedLine Citation:
PMID:  10535335     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iron supplementation in pregnancy is a controversial issue. The aim of this review was to summarize the results of relevant papers on this subject. METHODS: Placebo-controlled studies on iron treatment in pregnancy were identified from the Cochrane database. RESULTS: Among fertile women, 20% have iron reserves of >500 mg, which is the required minimum during pregnancy; 40% have iron stores of 100-500 mg, and 40% have virtually no iron stores. The demand for absorbed iron increases from 0.8 mg/day in early pregnancy to 7.5 mg/day in late pregnancy. Dietary iron intake in fertile women is median 9 mg/day, i.e. the majority of women have an intake below the estimated allowance of 12 18 mg/day. Iron absorption increases in pregnancy, but not enough to prevent iron deficiency anemia in 20%, of women not taking supplementary iron. Iron-treated pregnant women have greater iron reserves, higher hemoglobin levels, and a lower prevalence of iron deficiency anemia than placebo-treated women both in pregnancy as well as postpartum. Furthermore, children born to iron-treated mothers have higher serum ferritin levels than those born to placebo-treated mothers. An iron supplement of 65 mg/day from 20 weeks of gestation is adequate to prevent iron deficiency anemia. CONCLUSIONS: In order to avoid iron deficiency in pregnancy, prophylactic iron supplement should be considered. Iron supplements may be administered on a general or selective basis. The selective approach implies screening with serum ferritin in early pregnancy, in order to identify women who can manage without prophylactic iron.
N Milman; T Bergholt; K E Byg; L Eriksen; N Graudal
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  78     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-10     Completed Date:  1999-11-10     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  749-57     Citation Subset:  IM    
Department of Medicine, Naestved Hospital, Denmark.
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MeSH Terms
Anemia, Iron-Deficiency / blood,  epidemiology,  metabolism,  prevention & control*
Clinical Trials as Topic
Dietary Supplements* / adverse effects
Erythrocytes / metabolism
Erythropoietin / blood
Ferritins / blood
Hemoglobins / metabolism
Infant, Newborn / blood,  metabolism
Iron, Dietary / administration & dosage*,  adverse effects,  blood,  metabolism
Postpartum Period / blood
Pregnancy Complications / blood,  epidemiology,  metabolism,  prevention & control*
Receptors, Transferrin / biosynthesis
Time Factors
Reg. No./Substance:
0/Hemoglobins; 0/Iron, Dietary; 0/Receptors, Transferrin; 11096-26-7/Erythropoietin; 9007-73-2/Ferritins
Comment In:
Acta Obstet Gynecol Scand. 2000 Jul;79(7):620-1   [PMID:  10929970 ]

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