| Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans. | |
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MedLine Citation:
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PMID: 16522911 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although ferric pyrophosphate is a promising compound for iron fortification of foods, few data are available on the effect of food matrices, processing, and ascorbic acid on its bioavailability. OBJECTIVE: We compared the relative bioavailability (RBV) of ferrous sulfate in an experimental form of micronized dispersible ferric pyrophosphate (MDFP) in a wheat-milk infant cereal given with and without ascorbic acid with the RBV of MDFP from a processed and unprocessed rice meal. DESIGN: A crossover design was used to measure iron absorption in young women (n = 26) from test meals fortified with isotopically labeled [57Fe]-MDFP and [58Fe]-ferrous sulfate, based on erythrocyte incorporation of stable isotope labels 14 d later. RESULTS: Geometric mean iron absorption from the wheat-based meal fortified with MDFP was 2.0% and that from the meal fortified with ferrous sulfate was 3.2% (RBV = 62). The addition of ascorbic acid at a molar ratio of 4:1 to iron increased iron absorption from MDFP to 5.8% and that from ferrous sulfate to 14.8% (RBV = 39). In the rice meals, mean iron absorption from MDFP added to the rice at the time of feeding was 1.7%, and that from ferrous sulfate was 11.6% (RBV = 15). The mean iron absorption from MDFP extruded into artificial rice grains was 3.0% and that from ferrous sulfate in unprocessed rice was 12.6% (RBV = 24). Sixteen of 26 subjects were iron deficient. Iron status was a highly significant predictor of the RBV of MDFP (P < 0.001). CONCLUSION: RBV of the experimental MDFP varied markedly with food matrix and iron status. Assigning a single RBV value to poorly soluble compounds may be of limited value in evaluating their suitability for food fortification. |
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Authors:
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Diego Moretti; Michael B Zimmermann; Rita Wegmüller; Thomas Walczyk; Christophe Zeder; Richard F Hurrell |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 83 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-03-08 Completed Date: 2006-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 632-8 Citation Subset: AIM; IM |
Affiliation:
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Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zürich, Switzerland. diego.moretti@ilw.agrl.ethz.ch |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Absorption Adult Antioxidants / pharmacology* Ascorbic Acid / pharmacology* Biological Availability Cross-Over Studies Diphosphates / metabolism, pharmacokinetics* Female Ferritins / blood Ferrous Compounds / metabolism, pharmacokinetics* Food* Food Handling / methods* Food, Fortified Humans Intestinal Absorption / drug effects Iron / metabolism, pharmacokinetics* Iron Isotopes Nutritional Status Oryza sativa / chemistry Triticum / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 0/Diphosphates; 0/Ferrous Compounds; 0/Iron Isotopes; 10058-44-3/ferric pyrophosphate; 50-81-7/Ascorbic Acid; 7439-89-6/Iron; 7720-78-7/ferrous sulfate; 9007-73-2/Ferritins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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