Document Detail

Iron status and food matrix strongly affect the relative bioavailability of ferric pyrophosphate in humans.
MedLine Citation:
PMID:  16522911     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although ferric pyrophosphate is a promising compound for iron fortification of foods, few data are available on the effect of food matrices, processing, and ascorbic acid on its bioavailability. OBJECTIVE: We compared the relative bioavailability (RBV) of ferrous sulfate in an experimental form of micronized dispersible ferric pyrophosphate (MDFP) in a wheat-milk infant cereal given with and without ascorbic acid with the RBV of MDFP from a processed and unprocessed rice meal. DESIGN: A crossover design was used to measure iron absorption in young women (n = 26) from test meals fortified with isotopically labeled [57Fe]-MDFP and [58Fe]-ferrous sulfate, based on erythrocyte incorporation of stable isotope labels 14 d later. RESULTS: Geometric mean iron absorption from the wheat-based meal fortified with MDFP was 2.0% and that from the meal fortified with ferrous sulfate was 3.2% (RBV = 62). The addition of ascorbic acid at a molar ratio of 4:1 to iron increased iron absorption from MDFP to 5.8% and that from ferrous sulfate to 14.8% (RBV = 39). In the rice meals, mean iron absorption from MDFP added to the rice at the time of feeding was 1.7%, and that from ferrous sulfate was 11.6% (RBV = 15). The mean iron absorption from MDFP extruded into artificial rice grains was 3.0% and that from ferrous sulfate in unprocessed rice was 12.6% (RBV = 24). Sixteen of 26 subjects were iron deficient. Iron status was a highly significant predictor of the RBV of MDFP (P < 0.001). CONCLUSION: RBV of the experimental MDFP varied markedly with food matrix and iron status. Assigning a single RBV value to poorly soluble compounds may be of limited value in evaluating their suitability for food fortification.
Diego Moretti; Michael B Zimmermann; Rita Wegmüller; Thomas Walczyk; Christophe Zeder; Richard F Hurrell
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  83     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-08     Completed Date:  2006-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  632-8     Citation Subset:  AIM; IM    
Human Nutrition Laboratory, Institute of Food Science and Nutrition, Swiss Federal Institute of Technology, Zürich, Switzerland.
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MeSH Terms
Antioxidants / pharmacology*
Ascorbic Acid / pharmacology*
Biological Availability
Cross-Over Studies
Diphosphates / metabolism,  pharmacokinetics*
Ferritins / blood
Ferrous Compounds / metabolism,  pharmacokinetics*
Food Handling / methods*
Food, Fortified
Intestinal Absorption / drug effects
Iron / metabolism,  pharmacokinetics*
Iron Isotopes
Nutritional Status
Oryza sativa / chemistry
Triticum / chemistry
Reg. No./Substance:
0/Antioxidants; 0/Diphosphates; 0/Ferrous Compounds; 0/Iron Isotopes; 10058-44-3/ferric pyrophosphate; 50-81-7/Ascorbic Acid; 7439-89-6/Iron; 7720-78-7/ferrous sulfate; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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