Document Detail


Iron and oxidative stress in pregnancy.
MedLine Citation:
PMID:  12730487     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pregnancy, mostly because of the mitochondria-rich placenta, is a condition that favors oxidative stress. Transitional metals, especially iron, which is particularly abundant in the placenta, are important in the production of free radicals. Protective mechanisms against free radical generation and damage increase throughout pregnancy and protect the fetus, which, however, is subjected to a degree of oxidative stress. Oxidative stress peaks by the second trimester of pregnancy, ending what appears to be a vulnerable period for fetal health and gestational progress. Conditions restricted to pregnancy, such as gestational hypertension, insulin resistance and diabetes, exhibit exaggerated indications of free radical damage. Antioxidants as well as avoidance of iron excess ameliorate maternal and early fetal damage. In rats both iron deficiency and excess result in free radical mitochondrial damage. Estimates of gestational iron requirements and of the proportion of iron absorbed from different iron supplemental doses suggest that with present supplementation schemes the intestinal mucosal cells are constantly exposed to unabsorbed iron excess and oxidative stress. Unpublished work carried out in Mexico City with nonanemic women at midpregnancy indicates that 60 mg/d of iron increases the risk of hemoconcentration, low birth weight and premature birth and produces a progressive decline in plasma copper. These risks are not observed in women supplemented with 120 mg iron once or twice per week. Studies on the influence of iron supplementation schemes on oxidative stress are needed.
Authors:
Esther Casanueva; Fernando E Viteri
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 May 
Date Detail:
Created Date:  2003-05-05     Completed Date:  2003-06-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1700S-1708S     Citation Subset:  IM    
Affiliation:
Instituto Nacional de Perinatología, Mexico, DF, Mexico.
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MeSH Terms
Descriptor/Qualifier:
Diet
Dietary Supplements*
Female
Humans
Iron / adverse effects,  metabolism*
Oxidative Stress / physiology*
Pregnancy / physiology*
Pregnancy Complications / physiopathology*
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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