| Iron overload in patients undergoing hematopoietic stem cell transplantation. | |
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MedLine Citation:
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PMID: 20871852 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Recipients of hematopoietic stem cell transplantation (HSCT) frequently have iron overload resulting from chronic transfusion therapy for anemia. In some cases, for example, in patients with myelodysplastic syndromes and thalassemia, this can be further exacerbated by increased absorption of iron from the gut as a result of ineffective erythropoiesis. Accumulating evidence has established the negative impact of elevated pretransplantation serum ferritin, a surrogate marker of iron overload, on overall survival and nonrelapse mortality after HSCT. Complications of HSCT associated with iron overload include increased bacterial and fungal infections as well as sinusoidal obstruction syndrome and possibly other regimen-related toxicities. Based on current evidence, particular attention should be paid to prevention and management of iron overload in allogeneic HSCT candidates, especially in patients with thalassemia and myelodysplastic syndromes. The pathophysiology of iron overload in the HSCT patient and optimum strategies to deal with iron overload during and after HSCT require further study. |
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Authors:
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Vinod Pullarkat |
Publication Detail:
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Type: Journal Article Date: 2010-09-08 |
Journal Detail:
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Title: Advances in hematology Volume: 2010 ISSN: 1687-9112 ISO Abbreviation: Adv Hematol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-09-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101504271 Medline TA: Adv Hematol Country: Egypt |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Department of Hematology and Hematopoietic Cell Transplantation, City of Hope Medical Center, 150 East Duarte Road, Duarte, CA 91010, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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