Document Detail

Iron overload in MDS-pathophysiology, diagnosis, and complications.
MedLine Citation:
PMID:  20938663     Owner:  NLM     Status:  MEDLINE    
Many patients with myelodysplastic syndromes (MDS) become dependent on blood transfusions and develop transfusional iron overload, which is exacerbated by increased absorption of dietary iron in response to ineffective erythropoiesis. However, it is uncertain whether there is an association among iron accumulation, clinical complications, and decreased likelihood of survival in MDS patients. Here, we discuss our current understanding of the effects of transfusion dependency and iron overload in MDS, indicate our knowledge gaps, and suggest that particular emphasis should be placed on further characterizing the role of redox-active forms of labile iron, which may be as important as the total iron burden.
Norbert Gattermann; Eliezer A Rachmilewitz
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-10-12
Journal Detail:
Title:  Annals of hematology     Volume:  90     ISSN:  1432-0584     ISO Abbreviation:  Ann. Hematol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-03     Completed Date:  2011-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1-10     Citation Subset:  IM    
Department of Hematology, Oncology and Clinical Immunology, Heinrich-Heine-University, Mooren Str. 5, 40225, Düsseldorf, Germany.
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MeSH Terms
Blood Transfusion
Cell Transformation, Neoplastic / metabolism,  pathology
Iron Chelating Agents / therapeutic use
Iron Overload / complications*,  diagnosis*,  epidemiology,  etiology*
Life Expectancy
Models, Biological
Myelodysplastic Syndromes / complications*,  diagnosis,  epidemiology,  therapy
Oxidative Stress / physiology
Reg. No./Substance:
0/Iron Chelating Agents

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