Document Detail

Iron overload enhances epithelial cell proliferation in endometriotic lesions induced in a murine model.
MedLine Citation:
PMID:  16849816     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iron deposits are characteristic of endometriotic lesions, and pelvic iron concentrations are higher in endometriosis patients than in women without endometriosis. In this study, the effect of iron overload and iron chelation on the development of endometriosis in a murine model was investigated. METHODS: Human menstrual endometrium was injected i.p. into nude mice, either alone (controls) or supplemented with erythrocytes or desferrioxamine (DFO), an iron chelator. After 5 days, the iron load of endometriosis-like lesions and peritoneal macrophages and fluid was evaluated. Lesions were quantified by immunohistochemical morphometry, and their proliferative activity was assessed. RESULTS: Injection of erythrocytes into the pelvic cavity caused iron overload in lesions (P < 0.025) and peritoneal macrophages (P < 0.01) and fluid (P < 0.05), whereas DFO effectively reduced iron status in lesions (P < 0.05) and macrophages (P < 0.01) compared with controls. No difference was observed in the number or surface area of lesions between the three groups. Erythrocytes increased (P < 0.05) and DFO significantly decreased (P < 0.01) the proliferative activity of lesions. CONCLUSIONS: Iron overload does not appear to affect lesion establishment but may contribute to the further growth of endometriosis by promoting cell proliferation of lesions. Iron chelator treatment could therefore be beneficial in endometriosis to prevent iron overload in the pelvic cavity and decrease cellular proliferation of lesions.
Sylvie Defrère; Anne Van Langendonckt; Sophie Vaesen; Mathieu Jouret; Reinaldo González Ramos; Dolores Gonzalez; Jacques Donnez
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-18
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  21     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-10-12     Completed Date:  2007-01-29     Revised Date:  2007-02-06    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  England    
Other Details:
Languages:  eng     Pagination:  2810-6     Citation Subset:  IM    
Department of Gynaecology, Université Catholique de Louvain, Brussels, Belgium.
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MeSH Terms
Cell Division
Deferoxamine / therapeutic use
Disease Models, Animal
Disease Progression
Endometriosis / pathology*
Epithelial Cells / pathology*
Erythrocyte Transfusion
Iron Overload / complications,  pathology*,  prevention & control
Macrophages, Peritoneal
Mice, Nude
Transplantation, Heterologous
Reg. No./Substance:

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