| Iron overload cardiomyopathy: better understanding of an increasing disorder. | |
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MedLine Citation:
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PMID: 20846597 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The prevalence of iron overload cardiomyopathy (IOC) is increasing. The spectrum of symptoms of IOC is varied. Early in the disease process, patients may be asymptomatic, whereas severely overloaded patients can have terminal heart failure complaints that are refractory to treatment. It has been shown that early recognition and intervention may alter outcomes. Biochemical markers and tissue biopsy, which have traditionally been used to diagnose and guide therapy, are not sensitive enough to detect early cardiac iron deposition. Newer diagnostic modalities such as magnetic resonance imaging are noninvasive and can assess quantitative cardiac iron load. Phlebotomy and chelating drugs are suboptimal means of treating IOC; hence, the roles of gene therapy, hepcidin, and calcium channel blockers are being actively investigated. There is a need for the development of clinical guidelines in order to improve the management of this emerging complex disease. |
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Authors:
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Pradeep Gujja; Douglas R Rosing; Dorothy J Tripodi; Yukitaka Shizukuda |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Review |
Journal Detail:
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Title: Journal of the American College of Cardiology Volume: 56 ISSN: 1558-3597 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-17 Completed Date: 2010-10-07 Revised Date: 2012-04-26 |
Medline Journal Info:
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Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 1001-12 Citation Subset: AIM; IM |
Copyright Information:
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Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Division of Cardiovascular Diseases, Department of Internal Medicine, University of Cincinnati, Cincinnati, Ohio 45267-0542, USA. Pradeepg001@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Biological Markers
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blood Biopsy Cardiomyopathies / blood, diagnosis*, etiology, therapy* Critical Pathways Echocardiography Humans Iron / physiology Iron Overload / blood, complications, diagnosis*, therapy* Magnetic Resonance Imaging Myocardium / pathology Tomography, X-Ray Computed |
| Grant Support | |
ID/Acronym/Agency:
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Z99 HL999999/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 7439-89-6/Iron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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