| Iron overload, cardiac and other factors affecting pregnancy in thalassemia major. | |
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MedLine Citation:
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PMID: 20524814 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The reproductive thalassemic population is growing older and doctors confront the challenge of the thalassemic pregnancy. Pregnancy is characterized by dynamic multiple system changes, resulting in increased basal oxygen consumption, changes in energy substrate use by different organs and increased susceptibility to oxidative stress, while homozygous transfusion-dependent beta-thalassemia (beta-thal) patients manifest cardiac, hepatic, endocrine, and metabolic disorders attributable to chronic anoxia and iron overload. Pregnant thalassemic patients require significantly larger amount of total blood transfusion during pregnancy and iron overload increases the oxidative stress of pregnancy, while the risk for cardiovascular events, in a high cardiac output state, is augmented and chelation treatment is generally avoided due to the potential teratogenicity. Pregnancy in thalassemia major should be considered high risk, and be cared for by an expert team with special caution and sensitivity. |
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Authors:
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Maria Tsironi; Markissia Karagiorga; Athanasios Aessopos |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Hemoglobin Volume: 34 ISSN: 1532-432X ISO Abbreviation: Hemoglobin Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7705865 Medline TA: Hemoglobin Country: England |
Other Details:
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Languages: eng Pagination: 240-50 Citation Subset: IM |
Affiliation:
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Thalassaemia Unit, Department of Internal Medicine, Sparta General Hospital, Sparta, Greece. mtsironi@ otenet.gr |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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