| Iron overload: accuracy of in-phase and out-of-phase MRI as a quick method to evaluate liver iron load in haematological malignancies and chronic liver disease. | |
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MedLine Citation:
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PMID: 21385919 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Objectives: The purpose of this prospective study was to evaluate the accuracy of in-phase and out-of-phase imaging to assess hepatic iron concentration in patients with haematological malignancies and chronic liver disease. Methods: MRI-based hepatic iron concentration (M-HIC, μmol g(-1)) was used as a reference standard. 42 patients suspected of having iron overload and 12 control subjects underwent 1.5 T in- and out-of-phase and M-HIC liver imaging. Two methods, semi-quantitative visual grading made by two independent readers and quantitative relative signal intensity (rSI) method from SI differences of in-phase and out-of-phase images, were used. Statistical analyses were performed using the Spearman and Kruskal-Wallis test, receiver operator curve and κ coefficient. Results: The correlations between M-HIC and visual grading of Reader 1 (r  =  0.9534, p < 0.0001) and Reader 2 (r  =  0.9456, p < 0.0001)] were higher than the correlation of the rSI method (r  =  0.7719, p < 0.0001). There was excellent agreement between the readers (weighted κ  =  0.9619). Both visual grading and rSI were similar in detecting liver iron overload: rSI with 84.85% sensitivity, 100% specificity, and visual grading with 85% sensitivity and 100% specificity. The differences between the grades of visual grading were significant (p < 0.0001) and the method was able to distinguish different degrees of iron overload at the threshold of 151 μmol g(-1) with 100% positive predictive value and negative predictive value. Conclusion: Detection and grading of liver iron can be done reliably with in-phase and out-of-phase imaging. Liver fat is a potential pitfall, which limits the use of rSI. |
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Authors:
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J M Virtanen; T K Pudas; J A Ratilainen; J P Saunavaara; M E Komu; R K Parkkola |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-3-8 |
Journal Detail:
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Title: The British journal of radiology Volume: - ISSN: 1748-880X ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-3-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Radiology, Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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