| Iron mobilization in the pregnant rat. | |
| | |
MedLine Citation:
|
PMID: 1009023 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Iron exchange in the pregnant rat was quantitated by repeated determinations of plasma iron turnover (PIT), transferrin iron distribution and measurements of storage iron and food iron utilization employing selective radio-iron probes. Despite a sixfold increase in PIT, intestinal absorption of iron accounted for 40% of the PIT throughout pregnancy, with variations not exceeding +/- 5%. Increased fetal requirements were efficiently compensated for by the mobilization of iron from maternal tissue stores and by increased absorption, and there was no subsequent reduction in iron supply to maternal tissues. Enhancement of iron absorption occurred in the absence of a reduction in serum iron levels or the size of iron stores. In view of the close correlation between PIT and rates of absorption it is postulated that iron absorption in the pregnant rat is regulated by PIT which in turn is determined by the rate of plasma iron clearance by the placenta and the maternal erythroid marrow. |
| | |
Authors:
|
C Hershko; H Cohen; G Zajicek |
Related Documents
:
|
6879253 - Malnutrition and pregnancy wastage in zambia. 1628603 - Carbohydrate analysis of transferrin subfractions isolated by preparative isoelectric f... 7820303 - Sequential changes in intercellular junctions between hepatocytes during the course of ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: British journal of haematology Volume: 33 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1976 Aug |
Date Detail:
|
Created Date: 1977-03-21 Completed Date: 1977-03-21 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 505-16 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Body Weight Female Food Intestinal Absorption Iron / blood, metabolism* Liver / metabolism Maternal-Fetal Exchange Organ Size Pregnancy Pregnancy, Animal* Rats Spleen / metabolism Time Factors Transferrin / metabolism Uterus / anatomy & histology, metabolism |
| Chemical | |
Reg. No./Substance:
|
11096-37-0/Transferrin; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The uptake of ferric iron by rat liver ferritin in vivo and in vitro.
Next Document: Effect of iron deficiency and desferrioxamine on DNA synthesis in human cells.