Document Detail

Iron metabolism and lipid peroxidation products in infants with hypoxic ischemic encephalopathy.
MedLine Citation:
PMID:  18322549     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Iron delocalization or misregulation of iron metabolism may play a critical role in the pathology of hypoxic ischemic encephalopathy (HIE). OBJECTIVE: To study iron metabolism and lipid peroxidation in newborn infants and to correlate non-protein-bound iron (NPBI) concentration with the severity of the post-asphyxial injury and subsequent short-term outcomes. STUDY DESIGN: Concentrations of NPBI and malondialdehyde (MDA) in the serum and in the cerebrospinal fluid (CSF) were measured in eight healthy newborn infants and nine newborn infants suffering from moderately severe HIE. Short-term outcomes (death, survival with or without neurological abnormality) were noted at hospital discharge. RESULT: Serum and CSF concentrations of both NPBI and MDA were significantly increased in HIE infants when compared to controls. Serum iron was significantly increased and total iron binding capacity was significantly decreased in HIE infants compared to controls. Out of the nine HIE infants, four infants died and two infants survived with abnormal neurological findings at hospital discharge. These six infants with clinical sequels had significantly increased concentrations of NPBI in the serum and in the CSF; and increased concentrations of MDA in the CSF when compared to the other three who survived without short-term abnormalities. CONCLUSION: We conclude that hypoxia ischemia alters iron metabolism and lipid peroxidation in newborn infants; and that NPBI and MDA in the CSF are increased in infants with HIE. This study supports a role for iron in oxidative injury to the central nervous system after hypoxic ischemic insults.
B O Shouman; A Mesbah; H Aly
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Publication Detail:
Type:  Journal Article     Date:  2008-03-06
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  28     ISSN:  1476-5543     ISO Abbreviation:  J Perinatol     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-30     Completed Date:  2008-10-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  487-91     Citation Subset:  IM    
Department of Pediatrics, Mansoura University Faculty of Medicine, Mansoura, Egypt.
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MeSH Terms
Biological Markers / cerebrospinal fluid
Case-Control Studies
Hypoxia-Ischemia, Brain / blood,  cerebrospinal fluid,  metabolism*
Infant, Newborn
Iron / blood,  cerebrospinal fluid,  metabolism*
Lipid Peroxidation*
Malondialdehyde / blood,  cerebrospinal fluid*
Prospective Studies
Reg. No./Substance:
0/Biological Markers; 542-78-9/Malondialdehyde; 7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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