Document Detail


Iron involvement in neural damage and microgliosis in models of neurodegenerative diseases.
MedLine Citation:
PMID:  10875437     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In several neurodegenerative diseases, iron accumulates at sites of brain pathology. Since post-mortem examination cannot distinguish whether iron accumulation caused the damage or resulted from damage, it is necessary to manipulate iron in animal and tissue culture models to assess its causal role(s). However, only in models of Parkinson's disease and of global ischemia, iron deprivation (ID) or iron-chelators have been used to protect from damage. In these studies, documentation of microgliosis was not performed even though several lines of evidence converge to suggest that activation of microglia is an important source of oxidative stress. In the kainate model of epilepsy, we found that ID protected the olfactory cortex, thalamus and hippocampus and attenuated microgliosis, whereas iron supplementation to ID rats increased damage and microgliosis in the above regions. In the hilus of the hippocampal dentate gyrus, even though no cell loss was observed, ID attenuated microgliosis and iron-supplementation increased it. Thus there is a tight relationship between iron and microgliosis. In addition, iron+zinc supplementation dramatically increased damage to hippocampal CA1 whereas zinc supplementation alone had no effect. This study demonstrates an anatomically unique interaction of iron and zinc, which may lead to new insights to neurodegeneration in epilepsy.
Authors:
S Shoham; M B Youdim
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cellular and molecular biology (Noisy-le-Grand, France)     Volume:  46     ISSN:  0145-5680     ISO Abbreviation:  Cell. Mol. Biol. (Noisy-le-grand)     Publication Date:  2000 Jun 
Date Detail:
Created Date:  2000-09-29     Completed Date:  2000-10-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9216789     Medline TA:  Cell Mol Biol (Noisy-le-grand)     Country:  FRANCE    
Other Details:
Languages:  eng     Pagination:  743-60     Citation Subset:  IM    
Affiliation:
Research Department, Herzog Hospital, Jerusalem, Israel. sshoham@md2.huji.ac.il
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MeSH Terms
Descriptor/Qualifier:
Alzheimer Disease / metabolism
Animals
Brain / metabolism,  pathology
Diet
Epilepsy / metabolism
Friedreich Ataxia / metabolism
Humans
Huntington Disease / metabolism
Iron / metabolism*
Male
Microglia / metabolism*,  pathology
Multiple Sclerosis / metabolism
Neurodegenerative Diseases / etiology,  metabolism*
Neurons / metabolism*,  pathology
Pantothenate Kinase-Associated Neurodegeneration / metabolism
Rats
Rats, Sprague-Dawley
Reperfusion Injury / metabolism
Chemical
Reg. No./Substance:
7439-89-6/Iron

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