Document Detail


Iron indices and vitamin D receptor polymorphisms in hemodialysis patients.
MedLine Citation:
PMID:  18334245     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiovascular disease caused by accelerated atherosclerosis is the major determinant of morbidity and mortality in chronic kidney disease patients. Vitamin D and its analogs provide survival benefit for hemodialysis (HD) patients. Vitamin D exerts its effects through the vitamin D receptor (VDR) that is coded for by a gene showing several polymorphisms that, in turn, are associated with a variety of diseases and differential responses to vitamin D. In this study, we evaluated the association between 4 VDR polymorphisms (ie, those identified by the restriction enzymes BsmI, ApaI, TaqI, and FokI) and iron indices (serum iron, transferrin, transferrin saturation, and ferritin) in 88 hemodialysis patients routinely treated with vitamin D. The absence or presence of the BsmI, ApaI, TaqI, and FokI restriction sites were denominated B and b, A and a, T and t, F and f, respectively. Our results show that in HD patients with transferrin saturation <20%, the F allele was more frequent than in HD patients with transferrin saturation >20% (P = .03). This relationship may provide a link between VDR alleles and iron and nutritional markers, which are highly predictive variables of cardiovascular morbidity and mortality in hemodialysis patients.
Authors:
Marcello Amato; Stefania Pacini; Stefano Aterini; Tiziana Punzi; Massimo Gulisano; Marco Ruggiero
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Advances in chronic kidney disease     Volume:  15     ISSN:  1548-5609     ISO Abbreviation:  -     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-12     Completed Date:  2008-04-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101209214     Medline TA:  Adv Chronic Kidney Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-90     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Prato Hospital, Prato, Italy. nefrolog@usl4.toscana.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia, Iron-Deficiency / genetics*,  metabolism*,  mortality
Biological Markers / blood
Female
Ferritins / blood
Gene Frequency
Genetic Predisposition to Disease / epidemiology
Genotype
Humans
Iron / blood*
Kidney Failure, Chronic / genetics*,  metabolism*,  mortality,  therapy
Male
Middle Aged
Polymorphism, Genetic
Predictive Value of Tests
Receptors, Calcitriol / genetics*
Renal Dialysis
Transferrin / metabolism
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Calcitriol; 11096-37-0/Transferrin; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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