| Iron in sickle-cell disease: what have we learned over the years? | |
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MedLine Citation:
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PMID: 21157888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over the last four decades, monumental advances have been made in the understanding, assessment, and management of transfusion-dependent patients, which have translated into significant improvements in patient morbidity and mortality. Important lessons have been learned from extensive clinical experience of iron management in the thalassemias, but greater knowledge of key differences in the sickle-cell disease (SCD) population may impact on our approach to patient assessment and management. The unique pathophysiology of SCD is reflected in a distinct pattern of iron loading with minimal organ-specific injury. An appreciation and understanding of these differences should allow us to develop tailored management approaches that optimize patient outcomes. |
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Authors:
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Adlette Inati; Evelyne Khoriaty; Khaled M Musallam |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-11-08 |
Journal Detail:
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Title: Pediatric blood & cancer Volume: 56 ISSN: 1545-5017 ISO Abbreviation: Pediatr Blood Cancer Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2010-12-15 Completed Date: 2011-01-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101186624 Medline TA: Pediatr Blood Cancer Country: United States |
Other Details:
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Languages: eng Pagination: 182-90 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Wiley-Liss, Inc. |
Affiliation:
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Division of Paediatric Haematology and Oncology, Children's Centre for Cancer and Blood Diseases, Rafik Hariri University Hospital, Beirut, Lebanon. adlette.inati@lau.edu.lb |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Sickle Cell
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metabolism,
therapy* Blood Transfusion / adverse effects* Humans Iron / metabolism* Iron Overload / etiology*, metabolism |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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