Document Detail


Iron in obesity. An ancient micronutrient for a modern disease.
MedLine Citation:
PMID:  19619262     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron is a necessary constituent of several macromolecules involved in cell metabolism, but, at the same time, it could be a potentially dangerous element. For this reason iron balance must be finely regulated. At present, obesity has been recognized as a worldwide public health problem. Excess body fat is associated with increased all-cause mortality and increased risk for several medical morbidities. Many studies have shown that obesity might increase the risk of iron deficiency but, at the same time, obese subjects exhibit high serum ferritin levels. Recent studies seem to indicate that obesity is associated with iron deficiency although the aetiology appears to be multifactorial and includes (i) A decrease in iron food intake; (ii) An impairment of intestinal iron uptake and iron release from stores because of an overexpression of hepcidin and (iii) Inadequate iron bioavailability because of inflammation. In addition, abnormal ferritin concentrations can be explained by chronic inflammation rather than by iron overload. The aim of the present article is to review current knowledge of iron and obesity.
Authors:
C Zafon; A Lecube; R Simó
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-07-10
Journal Detail:
Title:  Obesity reviews : an official journal of the International Association for the Study of Obesity     Volume:  11     ISSN:  1467-789X     ISO Abbreviation:  Obes Rev     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-05-03     Completed Date:  2010-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897395     Medline TA:  Obes Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  322-8     Citation Subset:  IM    
Affiliation:
Endocrinology Division, Hospital Universitari Vall, d'Hebron, Universitat Autonoma de Barcelona, Barcelona, Spain. 26276czl@comb.es
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adipose Tissue / metabolism*
Ferritins / metabolism*
Homeostasis
Humans
Iron / blood,  deficiency*,  metabolism*
Micronutrients / metabolism
Obesity / blood,  complications
Chemical
Reg. No./Substance:
0/Micronutrients; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Overweight and obesity in infants and pre-school children in the European Union: a review of existin...
Next Document:  The increased role of non-albicans species in candidaemia: results from a 3-year surveillance study.