Document Detail

Iron from nanocompounds containing iron and zinc is highly bioavailable in rats without tissue accumulation.
MedLine Citation:
PMID:  20418865     Owner:  NLM     Status:  MEDLINE    
Effective iron fortification of foods is difficult, because water-soluble compounds that are well absorbed, such as ferrous sulphate (FeSO(4)), often cause unacceptable changes in the colour or taste of foods. Poorly water-soluble compounds, on the other hand, cause fewer sensory changes, but are not well absorbed. Here, we show that poorly water-soluble nanosized Fe and Fe/Zn compounds (specific surface area approximately 190 m(2) g(-1)) made by scalable flame aerosol technology have in vivo iron bioavailability in rats comparable to FeSO(4) and cause less colour change in reactive food matrices than conventional iron fortificants. The addition of Zn to FePO(4) and Mg to Fe/Zn oxide increases Fe absorption from the compounds, and doping with Mg also improves their colour. After feeding rats with nanostructured iron-containing compounds, no stainable Fe was detected in their gut wall, gut-associated lymphatics or other tissues, suggesting no adverse effects. Nanosizing of poorly water-soluble Fe compounds sharply increases their absorption and nutritional value.
Florentine M Hilty; Myrtha Arnold; Monika Hilbe; Alexandra Teleki; Jesper T N Knijnenburg; Felix Ehrensperger; Richard F Hurrell; Sotiris E Pratsinis; Wolfgang Langhans; Michael B Zimmermann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-25
Journal Detail:
Title:  Nature nanotechnology     Volume:  5     ISSN:  1748-3395     ISO Abbreviation:  Nat Nanotechnol     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-07     Completed Date:  2010-09-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101283273     Medline TA:  Nat Nanotechnol     Country:  England    
Other Details:
Languages:  eng     Pagination:  374-80     Citation Subset:  IM    
Human Nutrition Laboratory, Institute of Food, Nutrition and Health, ETH Zurich, Schmelzbergstrasse 7, Zürich, Switzerland.
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MeSH Terms
Biological Availability
Feeding Behavior
Food, Fortified
Hemoglobins / metabolism
Iron / metabolism*
Nanoparticles / chemistry*,  ultrastructure
Organ Specificity
Rats, Sprague-Dawley
Thiobarbituric Acid Reactive Substances / metabolism
Weight Gain
Zinc / metabolism*
Reg. No./Substance:
0/Hemoglobins; 0/Thiobarbituric Acid Reactive Substances; 7439-89-6/Iron; 7440-66-6/Zinc
Comment In:
Nat Nanotechnol. 2010 May;5(5):318-9   [PMID:  20418864 ]

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