Document Detail


Iron, ferritin, and nutrition.
MedLine Citation:
PMID:  15189124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ferritin, a major form of endogenous iron in food legumes such as soybeans, is a novel and natural alternative for iron supplementation strategies where effectiveness is limited by acceptability, cost, or undesirable side effects. A member of the nonheme iron group of dietary iron sources, ferritin is a complex with Fe3+ iron in a mineral (thousands of iron atoms inside a protein cage) protected from complexation. Ferritin illustrates the wide range of chemical and biological properties among nonheme iron sources. The wide range of nonheme iron receptors matched to the structure of the iron complexes that occurs in microorganisms may, by analogy, exist in humans. An understanding of the chemistry and biology of each type of dietary iron source (ferritin, heme, Fe2+ ion, etc.), and of the interactions dependent on food sources, genes, and gender, is required to design diets that will eradicate global iron deficiency in the twenty-first century.
Authors:
Elizabeth C Theil
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annual review of nutrition     Volume:  24     ISSN:  0199-9885     ISO Abbreviation:  Annu. Rev. Nutr.     Publication Date:  2004  
Date Detail:
Created Date:  2004-06-10     Completed Date:  2004-11-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8209988     Medline TA:  Annu Rev Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  327-43     Citation Subset:  IM    
Affiliation:
CHORI (Children's Hospital Oakland Research Institute), Oakland, California 94609, USA. etheil@chori.org
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Dietary Supplements
Ferritins / metabolism,  pharmacokinetics*
Humans
Iron / deficiency*,  metabolism
Iron, Dietary / administration & dosage,  pharmacokinetics*
Nutritional Physiological Phenomena*
Rats
Chemical
Reg. No./Substance:
0/Iron, Dietary; 7439-89-6/Iron; 9007-73-2/Ferritins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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