Document Detail

Iron and exercise induced alterations in antioxidant status. Protection by dietary milk proteins.
MedLine Citation:
PMID:  17390518     Owner:  NLM     Status:  MEDLINE    
Lipid peroxidation stress induced by iron supplementation can contribute to the induction of gut lesions. Intensive sports lead to ischemia reperfusion, which increases free radical production. Athletes frequently use heavy iron supplementation, whose effects are unknown. On the other hand, milk proteins have in vitro antioxidant properties, which could counteract these potential side effects. The main aims of the study were: (1) to demonstrate the effects of combined exercise training (ET) and iron overload on antioxidant status; (2) to assess the protective properties of casein in vivo; (3) to study the mechanisms involved in an in vitro model. Antioxidant status was assessed by measuring the activity of antioxidant enzymes (superoxide dismutase (SOD); glutathione peroxidase (GSH-Px)), and on the onset of aberrant crypts (AC) in colon, which can be induced by lipid peroxidation. At day 30, all ET animals showed an increase in the activity of antioxidant enzymes, in iron concentration in colon mucosa and liver and in the number of AC compared to untrained rats. It was found that Casein's milk protein supplementation significantly reduced these parameters. Additional information on protective effect of casein was provided by measuring the extent of TBARS formation during iron/ascorbate-induced oxidation of liposomes. Free casein and casein bound to iron were found to significantly reduce iron-induced lipid peroxidation. The results of the overall study suggest that Iron supplementation during intensive sport training would decrease anti-oxidant status. Dietary milk protein supplementation could at least partly prevent occurrence of deleterious effects to tissue induced by iron overload.
Gautier Zunquin; Vincent Rouleau; Said Bouhallab; Francois Bureau; Denis Theunynck; Pierre Rousselot; Pierre Arhan; Dominique Bougle
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Free radical research     Volume:  40     ISSN:  1071-5762     ISO Abbreviation:  Free Radic. Res.     Publication Date:  2006 May 
Date Detail:
Created Date:  2007-03-28     Completed Date:  2007-04-03     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  9423872     Medline TA:  Free Radic Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  535-42     Citation Subset:  IM    
Laboratoire de Physiologie digestive et nutritionnelle, CHU Caen, Caen, France.
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MeSH Terms
Caseins / administration & dosage*,  metabolism
Colon / metabolism,  pathology
Glutathione Peroxidase / metabolism
Iron / administration & dosage*,  metabolism
Iron Overload
Lipid Peroxidation* / drug effects
Liver / metabolism
Physical Conditioning, Animal
Rats, Sprague-Dawley
Superoxide Dismutase / metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Reg. No./Substance:
0/Caseins; 0/Thiobarbituric Acid Reactive Substances; 7439-89-6/Iron; EC Peroxidase; EC Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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