| Iron and early brain injury after subarachnoid hemorrhage. | |
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MedLine Citation:
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PMID: 20736954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aneurysmal subarachnoid hemorrhage (SAH) affects approximately 27,000 Americans per year. Although delayed cerebral vasospasm is of high clinical significance, mortality within the first 2 days may approach 30%. In this issue of the Journal of Cerebral Blood Flow and Metabolism, Lee et al have studied the role of iron in early brain injury after experimental SAH. They found that iron chelation with deferoxamine reduced mortality and oxidative DNA damage, and lessened the induction of iron-handling proteins. Taken together, these results highlight the deleterious potential of blood breakdown products and provide an insight into future intervention. |
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Authors:
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Matthew C Loftspring |
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Publication Detail:
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Type: Comment; Editorial Date: 2010-08-25 |
Journal Detail:
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Title: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism Volume: 30 ISSN: 1559-7016 ISO Abbreviation: J. Cereb. Blood Flow Metab. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-02 Completed Date: 2010-11-29 Revised Date: 2011-11-01 |
Medline Journal Info:
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Nlm Unique ID: 8112566 Medline TA: J Cereb Blood Flow Metab Country: United States |
Other Details:
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Languages: eng Pagination: 1791-2 Citation Subset: IM |
Affiliation:
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Department of Neurology, Neuroscience Graduate Program, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA. loftspmc@mail.uc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Diseases / etiology* DNA Damage / drug effects Deferoxamine / therapeutic use Humans Iron / metabolism* Iron Chelating Agents / therapeutic use Oxidative Stress / genetics Rats Subarachnoid Hemorrhage / complications*, drug therapy, metabolism*, mortality |
| Chemical | |
Reg. No./Substance:
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0/Iron Chelating Agents; 70-51-9/Deferoxamine; 7439-89-6/Iron |
| Comments/Corrections | |
Comment On:
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J Cereb Blood Flow Metab. 2010 Nov;30(11):1793-803
[PMID:
20736956
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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