Document Detail


Iron distribution in different tissues in rats following exercise.
MedLine Citation:
PMID:  11049216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron plays an essential role in blood oxygen transport and in muscle physiology. No conclusive data exist in the literature concerning its tissue distribution and behavior following exercise and training. The aim of the present work was to analyze the Fe content in different tissues following a single session of swimming to exhaustion and after swimming training in rats in order to more extensively describe the changes of Fe distribution provoked by exercise. Animals were divided into four groups (n=10): control group at rest, trained group at rest, control group after exercise, and trained group after exercise. First, rats swam until exhaustion and the maximal swimming time was noted. The training protocol consisted of swimming (5 d/week for 3 wk), limiting the time to 60% of the maximum obtained during the first session to exhaustion of each rat. The variables measured were erythrocytes, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, and, Fe in liver, kidney, erythrocytes, heart, muscle, bone, and serum. Variations in plasma volume were also calculated. Tissues presented two different profiles with regard to the changes of Fe concentration provoked by training: those displaying higher values of Fe after training, such as liver, heart, muscle, and serum, and those displaying lower values, such as bone, kidney, and red blood cells. These changes in the distribution of Fe in different tissues could be the result of an increase in the needs and use of Fe, shown by active tissues at exercise, and it is possible that the hormonal changes provoked by stress lead to a different behavior of Fe proteins.
Authors:
F J Navas; A Córdova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biological trace element research     Volume:  73     ISSN:  0163-4984     ISO Abbreviation:  Biol Trace Elem Res     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-16     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7911509     Medline TA:  Biol Trace Elem Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  259-68     Citation Subset:  IM    
Affiliation:
Department of Physiology, School of Physiotherapy and Medicine, Soria, University of Valladolid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Animals
Iron / metabolism*
Male
Physical Conditioning, Animal / physiology
Physical Exertion / physiology*
Rats
Rats, Wistar
Swimming / physiology
Tissue Distribution
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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