Document Detail

Iron deficiency of liver, heart, and brain in newborn infants of diabetic mothers.
MedLine Citation:
PMID:  1625067     Owner:  NLM     Status:  MEDLINE    
Infants of diabetic mothers frequently have polycythemia, elevated serum erythropoietin concentrations, and decreased serum iron and ferritin concentrations, likely representing a redistribution of fetal iron into erythrocytes to support augmented fetal hemoglobin synthesis. We hypothesized that fetal liver, heart, and brain iron concentrations are also reduced in these infants. After obtaining autopsy tissue from infants who had died before 7 days of age, we measured liver, heart, and brain iron concentrations using atomic absorption spectrophotometry. Seven infants of diabetic mothers and seven gestational age-matched control infants were studied. All infants of diabetic mothers had pancreatic islet cell hyperplasia, indicating fetal hyperglycemia and hyperinsulinemia. Liver iron concentrations in the infants of diabetic mothers were 6.6% of control values (489.0 +/- 154.4 vs 7379.7 +/- 1473.8 micrograms/gm dry tissue weight (mean +/- SEM); p less than 0.001), heart iron concentrations were 43.9% of control values (124.7 +/- 20.5 vs 284.1 +/- 34.8 micrograms/gm dry tissue weight; p less than 0.002), and brain iron concentrations were 60.6% of control values (106.1 +/- 13.7 vs 175.2 +/- 10.7 micrograms/gm dry tissue weight; p less than 0.003). Heart and brain iron concentrations were directly correlated with liver iron concentrations (r = 0.80 for both; p less than 0.001) and indicated that hepatic iron was greater than 75% depleted before heart and brain iron reduction. We conclude that severely affected infants of diabetic mothers have reduced liver, heart, and brain iron concentrations. The role of tissue iron deficiency in the genesis of the abnormal clinical findings in these infants deserves further consideration.
C D Petry; M A Eaton; J D Wobken; M M Mills; D E Johnson; M K Georgieff
Related Documents :
2485577 - The weanling: iron for all or one.
3439947 - Hydrops foetalis in sheep.
15074687 - Perrhenate uptake by iron and aluminum oxyhydroxides: an analogue for pertechnetate inc...
3872797 - Hypertension in a neonate with 11 beta-hydroxylase deficiency.
19151197 - Postnatal estradiol up-regulates lung nitric oxide synthases and improves lung function...
25242987 - Perinatal risk factors for neonatal asphyxia in vali-e-asr hospital, tehran-iran.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  121     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1992 Jul 
Date Detail:
Created Date:  1992-08-07     Completed Date:  1992-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  109-14     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Minnesota School of Medicine, Minneapolis.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anoxia / metabolism
Brain Chemistry*
Cerebral Cortex / chemistry
Fetal Diseases / metabolism
Hyperglycemia / metabolism
Hyperinsulinism / metabolism
Infant, Newborn / metabolism*
Iron / analysis*,  deficiency
Islets of Langerhans / pathology*
Liver / chemistry*
Myocardium / chemistry*
Pregnancy in Diabetics*
Retrospective Studies
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of neonatal polycythemia and hemodilution on capillary perfusion.
Next Document:  Unsuspected congenital heart disease in neonates receiving extracorporeal life support: a review of ...