| Iron deficiency and infant motor development. | |
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MedLine Citation:
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PMID: 18272298 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Iron deficiency (ID) during early development impairs myelination and basal ganglia function in animal models. AIMS: To examine the effects of iron deficiency anemia (IDA) and iron deficiency (ID) without anemia on infant motor skills that are likely related to myelination and basal ganglia function. STUDY DESIGN: Observational study. SUBJECTS: Full-term inner-city African-American 9- to 10-month-old infants who were free of acute or chronic health problems with iron status indicators ranging from IDA to iron sufficiency (n=106). Criteria for final iron status classification were met by 77 of these infants: 28 IDA, 28 non-anemic iron-deficient (NA ID), and 21 iron-sufficient (IS). OUTCOME MEASURES: Gross motor developmental milestones, Peabody Developmental Motor Scale, Infant Neurological International Battery (INFANIB), motor quality factor of the Bayley Behavioral Rating Scale, and a sequential/bi-manual coordination toy retrieval task. General linear model analyses tested for linear effects of iron status group and thresholds for effects. RESULTS: There were linear effects of iron status on developmental milestones, Peabody gross motor (suggestive trend), INFANIB standing item, motor quality, and toy retrieval. The threshold for effects was ID with or without anemia for developmental milestones, INFANIB standing item, and motor quality and IDA for toy retrieval. CONCLUSIONS: Using a comprehensive and sensitive assessment of motor development, this study found poorer motor function in ID infants with and without anemia. Poorer motor function among non-anemic ID infants is particularly concerning, since ID without anemia is not detected by common screening procedures and is more widespread than IDA. |
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Authors:
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Tal Shafir; Rosa Angulo-Barroso; Yuezhou Jing; Mary Lu Angelilli; Sandra W Jacobson; Betsy Lozoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2008-02-12 |
Journal Detail:
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Title: Early human development Volume: 84 ISSN: 0378-3782 ISO Abbreviation: Early Hum. Dev. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-06-13 Completed Date: 2008-09-15 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 7708381 Medline TA: Early Hum Dev Country: Ireland |
Other Details:
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Languages: eng Pagination: 479-85 Citation Subset: IM |
Affiliation:
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Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan 48109-5406, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anemia, Iron-Deficiency / blood, physiopathology* Child Development / physiology* Female Food, Fortified Humans Infant Infant Behavior / physiology Infant Formula / administration & dosage Iron / administration & dosage, blood Male Motor Activity / physiology* Psychomotor Performance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-01A10001/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-020001/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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