Document Detail


Iron deficiency and infant motor development.
MedLine Citation:
PMID:  18272298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Iron deficiency (ID) during early development impairs myelination and basal ganglia function in animal models.
AIMS: To examine the effects of iron deficiency anemia (IDA) and iron deficiency (ID) without anemia on infant motor skills that are likely related to myelination and basal ganglia function.
STUDY DESIGN: Observational study.
SUBJECTS: Full-term inner-city African-American 9- to 10-month-old infants who were free of acute or chronic health problems with iron status indicators ranging from IDA to iron sufficiency (n=106). Criteria for final iron status classification were met by 77 of these infants: 28 IDA, 28 non-anemic iron-deficient (NA ID), and 21 iron-sufficient (IS).
OUTCOME MEASURES: Gross motor developmental milestones, Peabody Developmental Motor Scale, Infant Neurological International Battery (INFANIB), motor quality factor of the Bayley Behavioral Rating Scale, and a sequential/bi-manual coordination toy retrieval task. General linear model analyses tested for linear effects of iron status group and thresholds for effects.
RESULTS: There were linear effects of iron status on developmental milestones, Peabody gross motor (suggestive trend), INFANIB standing item, motor quality, and toy retrieval. The threshold for effects was ID with or without anemia for developmental milestones, INFANIB standing item, and motor quality and IDA for toy retrieval.
CONCLUSIONS: Using a comprehensive and sensitive assessment of motor development, this study found poorer motor function in ID infants with and without anemia. Poorer motor function among non-anemic ID infants is particularly concerning, since ID without anemia is not detected by common screening procedures and is more widespread than IDA.
Authors:
Tal Shafir; Rosa Angulo-Barroso; Yuezhou Jing; Mary Lu Angelilli; Sandra W Jacobson; Betsy Lozoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-02-12
Journal Detail:
Title:  Early human development     Volume:  84     ISSN:  0378-3782     ISO Abbreviation:  Early Hum. Dev.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-13     Completed Date:  2008-09-15     Revised Date:  2013-06-05    
Medline Journal Info:
Nlm Unique ID:  7708381     Medline TA:  Early Hum Dev     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  479-85     Citation Subset:  IM    
Affiliation:
Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan 48109-5406, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anemia, Iron-Deficiency / blood,  physiopathology*
Child Development / physiology*
Female
Food, Fortified
Humans
Infant
Infant Behavior / physiology
Infant Formula / administration & dosage
Iron / administration & dosage,  blood
Male
Motor Activity / physiology*
Psychomotor Performance / physiology
Grant Support
ID/Acronym/Agency:
P01 HD039386-01A1/HD/NICHD NIH HHS; P01 HD039386-01A10001/HD/NICHD NIH HHS; P01 HD039386-02/HD/NICHD NIH HHS; P01 HD039386-020001/HD/NICHD NIH HHS; P01 HD039386-03/HD/NICHD NIH HHS; P01 HD039386-04/HD/NICHD NIH HHS; P01 HD039386-05/HD/NICHD NIH HHS; P01 HD39386/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
7439-89-6/Iron
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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