Document Detail


Iron deficiency in infancy: applying a physiologic framework for prediction.
MedLine Citation:
PMID:  17158425     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Infants aged 6-24 mo are at high risk of iron deficiency. Numerous studies worldwide have sought to identify predictors of iron deficiency in this age group.
OBJECTIVE: The objectives of the study were to apply a physiologic model to identify risk factors for iron deficiency and to consider those risk factors under different conditions of iron supplementation. We predicted that factors related to iron status at birth (lower gestational age and lower birth weight), postnatal needs for iron (more rapid growth), and bioavailable iron (more cow milk) would be major risk factors.
DESIGN: The physiologic framework was assessed in 1657 Chilean infants (aged 12 mo) with birth weights >or=3 kg who were randomly assigned at age 6 mo to high or low iron supplementation or no added iron. Based on venous blood, the analysis used mean corpuscular volume and concentrations of hemoglobin, free erythrocyte protoporphyrin, and ferritin. Logistic regression models were used to identify predictors of iron deficiency anemia and iron deficiency without anemia.
RESULTS: The prevalence of iron deficiency (>or=2 abnormal iron measures) was 34.9% at age 12 mo. Of 186 infants with hemoglobin concentrations <110 g/L, 158 (84.9%) were iron deficient. The only consistent (and the strongest) predictor of iron deficiency or iron deficiency anemia was lower 6-mo hemoglobin. Factors related to poorer iron status at birth (lower birth weight, shorter gestation though full-term, or both) were predictors in the no-added-iron and high-iron groups. Otherwise, predictors varied by iron supplementation.
CONCLUSION: Variations in predictors of iron deficiency or iron deficiency anemia according to iron supplementation suggest that direct comparisons across studies are tenuous at best without data on early iron status and certainty that specific conditions are comparable.
Authors:
Betsy Lozoff; Niko Kaciroti; Tomás Walter
Related Documents :
21281485 - Assessment of surfactant use in preterm infants as a marker of neonatal intensive care ...
17264625 - Iron status, serum folate and b(12) values in pregnancy and postpartum: report from a s...
20923825 - Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and y...
10215065 - Prenatal diagnosis and treatment of holocarboxylase synthetase deficiency.
6718115 - An abnormality of neutrophil adhesion: autosomal recessive inheritance associated with ...
21508705 - Antibiotics after preterm premature rupture of the membranes.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  84     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-01-09     Revised Date:  2013-06-06    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1412-21     Citation Subset:  AIM; IM    
Affiliation:
Center for Human Growth and Development, University of Michigan, Ann Arbor, MI 48109-0406, USA. blozoff@umich.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / blood,  drug therapy,  epidemiology*
Biological Availability
Birth Weight / physiology
Chile / epidemiology
Dietary Supplements
Erythrocyte Indices
Female
Ferritins / blood
Gestational Age
Hemoglobins / analysis
Humans
Infant
Infant Nutrition Disorders / blood,  drug therapy,  epidemiology*
Infant Nutritional Physiological Phenomena*
Iron / blood,  deficiency*
Iron, Dietary / administration & dosage,  pharmacokinetics*
Logistic Models
Male
Nutritional Requirements
Nutritional Status*
Predictive Value of Tests
Risk Factors
Trace Elements / blood,  deficiency
Grant Support
ID/Acronym/Agency:
HD14122/HD/NICHD NIH HHS; HD33487/HD/NICHD NIH HHS; R01 HD033487-03/HD/NICHD NIH HHS; R01 HD033487-03S1/HD/NICHD NIH HHS; R01 HD033487-04/HD/NICHD NIH HHS; R01 HD033487-04S1/HD/NICHD NIH HHS; R01 HD033487-05/HD/NICHD NIH HHS; R01 HD033487-06/HD/NICHD NIH HHS; R01 HD033487-07/HD/NICHD NIH HHS; R01 HD033487-08/HD/NICHD NIH HHS; R01 HD033487-09/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 0/Iron, Dietary; 0/Trace Elements; 7439-89-6/Iron; 9007-73-2/Ferritins
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Age...
Next Document:  Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment.