|Iron deficiency in infancy: applying a physiologic framework for prediction.|
|PMID: 17158425 Owner: NLM Status: MEDLINE|
|BACKGROUND: Infants aged 6-24 mo are at high risk of iron deficiency. Numerous studies worldwide have sought to identify predictors of iron deficiency in this age group.
OBJECTIVE: The objectives of the study were to apply a physiologic model to identify risk factors for iron deficiency and to consider those risk factors under different conditions of iron supplementation. We predicted that factors related to iron status at birth (lower gestational age and lower birth weight), postnatal needs for iron (more rapid growth), and bioavailable iron (more cow milk) would be major risk factors.
DESIGN: The physiologic framework was assessed in 1657 Chilean infants (aged 12 mo) with birth weights >or=3 kg who were randomly assigned at age 6 mo to high or low iron supplementation or no added iron. Based on venous blood, the analysis used mean corpuscular volume and concentrations of hemoglobin, free erythrocyte protoporphyrin, and ferritin. Logistic regression models were used to identify predictors of iron deficiency anemia and iron deficiency without anemia.
RESULTS: The prevalence of iron deficiency (>or=2 abnormal iron measures) was 34.9% at age 12 mo. Of 186 infants with hemoglobin concentrations <110 g/L, 158 (84.9%) were iron deficient. The only consistent (and the strongest) predictor of iron deficiency or iron deficiency anemia was lower 6-mo hemoglobin. Factors related to poorer iron status at birth (lower birth weight, shorter gestation though full-term, or both) were predictors in the no-added-iron and high-iron groups. Otherwise, predictors varied by iron supplementation.
CONCLUSION: Variations in predictors of iron deficiency or iron deficiency anemia according to iron supplementation suggest that direct comparisons across studies are tenuous at best without data on early iron status and certainty that specific conditions are comparable.
|Betsy Lozoff; Niko Kaciroti; Tomás Walter|
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|Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural|
|Title: The American journal of clinical nutrition Volume: 84 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2006 Dec|
|Created Date: 2006-12-12 Completed Date: 2007-01-09 Revised Date: 2014-09-17|
Medline Journal Info:
|Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States|
|Languages: eng Pagination: 1412-21 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Birth Weight / physiology
Chile / epidemiology
Ferritins / blood
Hemoglobins / analysis
Infant Nutrition Disorders / blood, drug therapy, epidemiology*
Infant Nutritional Physiological Phenomena*
Iron / blood, deficiency*
Iron, Dietary / administration & dosage, pharmacokinetics*
Predictive Value of Tests
Trace Elements / blood, deficiency
|HD14122/HD/NICHD NIH HHS; HD33487/HD/NICHD NIH HHS; R01 HD033487/HD/NICHD NIH HHS|
|0/Hemoglobins; 0/Iron, Dietary; 0/Trace Elements; 9007-73-2/Ferritins; E1UOL152H7/Iron|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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