Document Detail

Iron deficiency in infancy: applying a physiologic framework for prediction.
MedLine Citation:
PMID:  17158425     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Infants aged 6-24 mo are at high risk of iron deficiency. Numerous studies worldwide have sought to identify predictors of iron deficiency in this age group.
OBJECTIVE: The objectives of the study were to apply a physiologic model to identify risk factors for iron deficiency and to consider those risk factors under different conditions of iron supplementation. We predicted that factors related to iron status at birth (lower gestational age and lower birth weight), postnatal needs for iron (more rapid growth), and bioavailable iron (more cow milk) would be major risk factors.
DESIGN: The physiologic framework was assessed in 1657 Chilean infants (aged 12 mo) with birth weights >or=3 kg who were randomly assigned at age 6 mo to high or low iron supplementation or no added iron. Based on venous blood, the analysis used mean corpuscular volume and concentrations of hemoglobin, free erythrocyte protoporphyrin, and ferritin. Logistic regression models were used to identify predictors of iron deficiency anemia and iron deficiency without anemia.
RESULTS: The prevalence of iron deficiency (>or=2 abnormal iron measures) was 34.9% at age 12 mo. Of 186 infants with hemoglobin concentrations <110 g/L, 158 (84.9%) were iron deficient. The only consistent (and the strongest) predictor of iron deficiency or iron deficiency anemia was lower 6-mo hemoglobin. Factors related to poorer iron status at birth (lower birth weight, shorter gestation though full-term, or both) were predictors in the no-added-iron and high-iron groups. Otherwise, predictors varied by iron supplementation.
CONCLUSION: Variations in predictors of iron deficiency or iron deficiency anemia according to iron supplementation suggest that direct comparisons across studies are tenuous at best without data on early iron status and certainty that specific conditions are comparable.
Betsy Lozoff; Niko Kaciroti; Tomás Walter
Related Documents :
12163665 - The high prevalence of low hemoglobin concentration among indonesian infants aged 3-5 m...
22669085 - Insufficient androgen and fsh signaling may be responsible for the azoospermia of the i...
16076215 - In vitro characterization of salmochelin and enterobactin trilactone hydrolases irod, i...
3818925 - Bifidobacterium, bacteroides, and clostridium spp. in fecal samples from breast-fed and...
14726805 - Mutations in genes required for t-cell development: il7r, cd45, il2rg, jak3, rag1, rag2...
19864835 - Iron nutrition in infancy.
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  84     ISSN:  0002-9165     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-12     Completed Date:  2007-01-09     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1412-21     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anemia, Iron-Deficiency / blood,  drug therapy,  epidemiology*
Biological Availability
Birth Weight / physiology
Chile / epidemiology
Dietary Supplements
Erythrocyte Indices
Ferritins / blood
Gestational Age
Hemoglobins / analysis
Infant Nutrition Disorders / blood,  drug therapy,  epidemiology*
Infant Nutritional Physiological Phenomena*
Iron / blood,  deficiency*
Iron, Dietary / administration & dosage,  pharmacokinetics*
Logistic Models
Nutritional Requirements
Nutritional Status*
Predictive Value of Tests
Risk Factors
Trace Elements / blood,  deficiency
Grant Support
Reg. No./Substance:
0/Hemoglobins; 0/Iron, Dietary; 0/Trace Elements; 9007-73-2/Ferritins; E1UOL152H7/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Methylmalonic acid and cognitive function in the Medical Research Council Cognitive Function and Age...
Next Document:  Elevated serum S-adenosylhomocysteine in cobalamin-deficient elderly and response to treatment.