Document Detail

Iron deficiency in Yemeni patients with sickle-cell disease.
MedLine Citation:
PMID:  22574477     Owner:  NLM     Status:  In-Process    
Despite the general view that patients with sickle-cell disease (SCD) have iron overload, there are reports of iron deficiency in a proportion of these patients. We studied Yemeni patients aged 1-30 years with homozygous SCD to determine their iron status using a set of 4 criteria (low serum iron, low transferrin saturation, high total iron binding capacity and low mean corpuscular volume for age). Of the 75 patients, 44 had never been transfused while 31 patients had received blood transfusions but not during the 3-month period prior to the study. Of the patients, 10 (13.3%) met the criteria for iron deficiency, 9 of whom were from the non-transfused patients (20.5%). The sensitivity and specificity were 40% and 98% respectively for reticulocyte count and 80% and 90% respectively for reticulocyte index. We recommend screening non-transfused SCD patients for iron deficiency.
A Kassim; S Thabet; M Al-Kabban; K Al-Nihari
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Eastern Mediterranean health journal = La revue de santé de la Méditerranée orientale = al-Majallah al-ṣiḥḥīyah li-sharq al-mutawassiṭ     Volume:  18     ISSN:  1020-3397     ISO Abbreviation:  East. Mediterr. Health J.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-05-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9608387     Medline TA:  East Mediterr Health J     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  241-5     Citation Subset:  IM    
Department of Internal Medicine, Faculty of Medicine, University of Taiz, Taiz, Yemen.
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