Document Detail

Iron deficiency in Brazilian infants with sickle cell disease.
MedLine Citation:
PMID:  21842114     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess iron deficiency or overload in infants with sickle cell disease in order to support the decision to recommend (or not) iron prophylactic supplementation in this population. METHODS: Cross-sectional and retrospective study with 135 infants below 2 years old (66 boys and 69 girls), 77 with SS and 58 with SC hemoglobin, born between 2005 and 2006 in Minas Gerais, Brazil. Indicators of possible iron deficiency were: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), transferrin saturation (TS), and ferritin. Blood transfusions had been given to 17 infants (12.6%, 95% confidence interval [95%CI] 7.0-18.2%) before laboratory tests were done. RESULTS: Ferritin and TS were significantly lower in SC infants (p < 0.001). When two indices were considered for the definition of iron deficiency (low MCV or MCH plus low ferritin or TS), 17.8% of children (95%CI 11.3-24.3%) presented iron deficiency, mainly those with SC hemoglobin (p = 0.003). An analysis of infants who were not given transfusions (n = 118) showed that 19.5% presented iron deficiency. Fifteen infants (11.3%, 95%CI 5.9-16.7%) presented increased ferritin; the majority had been transfused. CONCLUSIONS: Most infants with sickle cell disease do not develop iron deficiency, though some have a significant deficit. This study indicates that infants with sickle cell disease, mainly those with SC hemoglobin, may receive prophylactic iron; however, supplementation should be withdrawn after the first blood transfusion.
Priscila C Rodrigues; Rocksane C Norton; Mitiko Murao; José N Januario; Marcos B Viana
Related Documents :
18728954 - Outlooks for the future in independently living older australians.
16328704 - Identifying multiple gestation groups using state-level birth and fetal death certifica...
11176744 - Problems with proper completion and accuracy of the cause-of-death statement.
11433874 - The southeast minnesota fetal and infant mortality reduction project.
24008304 - Preterm infants have altered adiponectin levels at term-equivalent age even if they do ...
9055144 - Visual acuity in extremely low birth weight infants.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-8-12
Journal Detail:
Title:  Jornal de pediatria     Volume:  87     ISSN:  1678-4782     ISO Abbreviation:  -     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-8-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985188R     Medline TA:  J Pediatr (Rio J)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Fundação Hemominas, Belo Horizonte, MG, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Association of air pollution and hematologic parameters in children and adolescents.
Next Document:  Seroprevalence of hepatitis A in children and adolescents.