Document Detail


Iron deficiency and child development.
MedLine Citation:
PMID:  18297894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iron deficiency is widespread in infants and young children, especially in developing countries. Animal models provide convincing evidence that, despite iron repletion, iron deficiency during the brain growth spurt alters metabolism and neurotransmission, myelination, and gene and protein profiles. In the human, there is compelling evidence that 6- to 24-month-old infants with iron-deficiency anemia are at risk for poorer cognitive, motor, social-emotional, and neurophysiologic development in the short- and long-term outcome. In contrast to inconsistent developmental effects of iron therapy for iron-deficient infants, recent large, randomized trials of iron supplementation in developing countries uniformly show benefits of iron, especially on motor development and social-emotional behavior. These results indicate that adverse effects can be prevented and/or reversed with iron earlier in development or before iron deficiency becomes severe or chronic. New findings also point to the need for more attention to the developmental effects of prenatal iron deficiency.
Authors:
Betsy Lozoff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Food and nutrition bulletin     Volume:  28     ISSN:  0379-5721     ISO Abbreviation:  Food Nutr Bull     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2008-02-26     Completed Date:  2008-03-28     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7906418     Medline TA:  Food Nutr Bull     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  S560-71     Citation Subset:  IM    
Affiliation:
Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, University of Michigan, 300 N. Ingalls, Ann Arbor, MI 48109-5406, USA. blozoff@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Anemia, Iron-Deficiency / complications*,  prevention & control
Animals
Brain / embryology,  growth & development*,  metabolism
Child Development / drug effects*
Child, Preschool
Cognition / drug effects,  physiology
Disease Models, Animal
Female
Humans
Infant
Iron / deficiency*,  therapeutic use*
Male
Nutritional Requirements
Pregnancy
Prenatal Nutritional Physiological Phenomena
Grant Support
ID/Acronym/Agency:
P01 HD39386/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
7439-89-6/Iron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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