| Iron deficiency and child development. | |
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MedLine Citation:
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PMID: 18297894 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Iron deficiency is widespread in infants and young children, especially in developing countries. Animal models provide convincing evidence that, despite iron repletion, iron deficiency during the brain growth spurt alters metabolism and neurotransmission, myelination, and gene and protein profiles. In the human, there is compelling evidence that 6- to 24-month-old infants with iron-deficiency anemia are at risk for poorer cognitive, motor, social-emotional, and neurophysiologic development in the short- and long-term outcome. In contrast to inconsistent developmental effects of iron therapy for iron-deficient infants, recent large, randomized trials of iron supplementation in developing countries uniformly show benefits of iron, especially on motor development and social-emotional behavior. These results indicate that adverse effects can be prevented and/or reversed with iron earlier in development or before iron deficiency becomes severe or chronic. New findings also point to the need for more attention to the developmental effects of prenatal iron deficiency. |
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Authors:
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Betsy Lozoff |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
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Title: Food and nutrition bulletin Volume: 28 ISSN: 0379-5721 ISO Abbreviation: Food Nutr Bull Publication Date: 2007 Dec |
Date Detail:
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Created Date: 2008-02-26 Completed Date: 2008-03-28 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7906418 Medline TA: Food Nutr Bull Country: Japan |
Other Details:
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Languages: eng Pagination: S560-71 Citation Subset: IM |
Affiliation:
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Center for Human Growth and Development, Department of Pediatrics and Communicable Diseases, University of Michigan, 300 N. Ingalls, Ann Arbor, MI 48109-5406, USA. blozoff@umich.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Iron-Deficiency
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complications*,
prevention & control Animals Brain / embryology, growth & development*, metabolism Child Development / drug effects* Child, Preschool Cognition / drug effects, physiology Disease Models, Animal Female Humans Infant Iron / deficiency*, therapeutic use* Male Nutritional Requirements Pregnancy Prenatal Nutritional Physiological Phenomena |
| Grant Support | |
ID/Acronym/Agency:
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P01 HD39386/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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